19541-95-8

Basic information

• Product Name: 5-AMINO-3-(4-METHOXYPHENYL)PYRAZOLE
• Synonyms: BUTTPARK 34\07-83;CHEMBRDG-BB 4004590;5-(4-METHOXY-PHENYL)-2H-PYRAZOL-3-YLAMINE;5-AMINO-3-(4-METHOXYPHENYL)PYRAZOLE;3-(4-METHOXYPHENYL)-1H-PYRAZOL-5-AMINE;SALOR-INT L317888-1EA;3-Amino-5-(4-methoxyphenyl)-1H-pyrazole;5-(4-methoxyphenyl)-1H-pyrazol-3-amine
• CAS NO: 19541-95-8
• Molecular Formula: C₁₀H₁₁N₃O
• Molecular Weight: 189.21
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Pyrazoles;Heterocycles
• Mol File: 19541-95-8.mol
• Article Data: 26

Chemical Properties

• Melting Point: 143-145°C
• Boiling Point: 466.392 °C at 760 mmHg
• Flash Point: 235.866 °C
• Appearance: /
• Density: 1.24 g/cm³
• Vapor Pressure: 7.11E-09mmHg at 25°C
• Refractive Index: 1.63
• Solubility: soluble in Methanol
• PKA: 14.88±0.10(Predicted)
• CAS DataBase Reference: 5-AMINO-3-(4-METHOXYPHENYL)PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-3-(4-METHOXYPHENYL)PYRAZOLE(19541-95-8)
• EPA Substance Registry System: 5-AMINO-3-(4-METHOXYPHENYL)PYRAZOLE(19541-95-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 19541-95-8(Hazardous Substances Data)

Usage

General Description

5-Amino-3-(4-methoxyphenyl)pyrazole is a chemical compound with the molecular formula C10H10N4O. It is a pyrazole derivative with a substituted phenyl group. This chemical is known for its potential use in pharmaceutical and medicinal research due to its ability to inhibit certain enzymes and receptors. It has also been studied for its potential application in the treatment of cancer and other diseases. Additionally, 5-Amino-3-(4-methoxyphenyl)pyrazole may also have applications in the development of organic dyes and pigments. Overall, this chemical compound has shown promise in various fields, making it an interesting subject for further research and development.

InChI:InChI=1/C10H11N3O/c1-14-8-4-2-7(3-5-8)9-6-10(11)13-12-9/h2-6H,1H3,(H3,11,12,13)

Upstream product

• 3672-47-7 3-oxo-3-(4'-methoxyphenyl)propanenitrile 
• 3672-48-8 5-(4-methoxyphenyl)-1,2-oxazole 
• 121-98-2 methyl 4-methoxybenzoate 
• 14063-79-7 3-chloro-3-(4-methoxyphenyl)acrylaldehyde 
• 57466-68-9 3-chloro-3-(4-methoxyphenyl)acrylonitrile 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 90799-51-2 2-Chlor-3-<4-methoxy-phenyl>-acrylnitril 
• 35070-82-7 2-(4-methoxyphenyl)-3-oxopropanenitrile 
• 138175-63-0 (Z)-3-Bromo-2-ethylsulfanyl-3-(4-methoxy-phenyl)-acrylonitrile 
• 55991-65-6 [1-(4-methoxyphenyl)vinyloxy]trimethylsilane 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 1040725-00-5 C₁₆H₂₀BrN₃O₂ 
• 1040724-60-4 5-bromo-pentanoic acid [5-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-amide 
• 1040724-60-4 5-bromo-pentanoic acid [5-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-amide 
• 1245236-07-0 C₂₂H₁₉Cl₂N₃O₃ 
• 1258222-95-5 C₂₈H₃₁N₉O₂S 
• 1159982-73-6 5,7-dichloro-2-(4-methoxy-phenyl)-pyrazolo[1,5-a]pyrimidine 
• 1232220-39-1 N-{2-(4-methoxy-phenyl)-7-morpholin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl}-N-(3-methyl-benzylidene)-hydrazine 
• 1232223-29-8 5-chloro-2-(4-methoxy-phenyl)-7-morpholin-4-yl-pyrazolo[1,5-a]pyrimidine 
• 1448466-64-5 1,3-dihydro-7-(4-methoxyphenyl)pyrazolo[1,5-a][1,3,5]triazin-2-thioxo-4-one 

Relevant articles and documents

Synthesis of some novel fluorinated pyrazolo[3,4-b]pyridines

Reaction of 5-amino-3-substituted pyrazoles (1a-c) and 5-amino-1,3- disubstituted pyrazoles (1d-i) with fluorinated-β-diketones (2) results in the formation of the single isomer of pyrazolo[3,4-b]pyridines (4a-h). A one-pot procedure for the synthesis of

Novel benzenesulfonamide-bearing pyrazoles and 1,2,4-thiadiazoles as selective carbonic anhydrase inhibitors

Two series comprising 20 novel benzenesulfonamides bearing thioureido-linked pyrazole 8 and amino-1,2,4-thiadiazole 10 were synthesized and assayed as human carbonic anhydrase (hCA) inhibitors against isoforms I and II as well as the tumor-associated isof

Modular synthesis and antiproliferative activity of new dihydro-1H-pyrazolo[1,3-b]pyridine embelin derivatives

A set of new dihydro-1H-pyrazolo[1,3-b]pyridine and pyrazolo[1,3-b]pyridine embelin derivatives was synthesized through a multicomponent reaction from natural embelin, 3-substituted-5-aminopyrazoles and aldehydes. The synthesized compounds were evaluated against three hematologic tumor cell lines, HEL (acute erythroid leukemia), K-562 (chronic myeloid leukemia) and HL-60 (acute myeloid leukemia), and five breast cancer cell lines (SKBR3, MCF-7, MDA-MB-231, BT-549, HS-578T). The primate non-malignant kidney Vero cell line was used as the control of cytotoxicity. From the obtained results, some structure–activity relationships were out-lined. Furthermore, in silico prediction of physicochemical properties and ADME parameters were determined for the derivatives with the best antiproliferative values.

Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation

A simple one-pot method for the microwave-assisted synthesis of substituted pyrazolo[1,5-a]pyrimidinones, a core scaffold in many bioactive and pharmaceutically relevant compounds, has been established. A variety of substituents was tolerated at the 2 and 5 positions, including functionalized aryls, heterocycles, and alkyl groups.