1956-11-2Relevant articles and documents
FUNCTIONAL FLUOROCARBON MICELLES. PHASE SEPARATION AND REACTIVITY CHANGE OF HYDROXAMATE NUCLEOPHILES IN MIXED MICELLES OF HYDROCARBON AND FLUOROCARBON SURFACTANTS
Ihara, Hirotaka,Hashiguchi, Yuichi,Kunitake, Toyoki
, p. 733 - 736 (1983)
The titration behavior of long-chain(hydrocarbon and fluorocarbon) hydroxamic acids in the presence and absence of micellar matrices is influenced by phase separation of hydrocarbon and fluorocarbon species.The same factors operate in the hydrolysis of phenyl esters.
A domino Kornblum-DeLaMare/aza-Michael reaction of 3,6-dihydro-1,2-dioxines and application to the synthesis of the ceramide transport inhibitor (±)-HPA-12
Legendre, Sarah V.A.-M.,Jevric, Martyn,Klepp, Julian,Sumby, Christopher J.,Greatrex, Ben W.
, p. 1229 - 1239 (2017/12/04)
A Kornblum-DeLaMare/aza-Michael reaction of 3,6-dihydro-1,2-dioxines with primary and secondary amines has been developed which affords 4-hydroxy-3-aminoketones. The aza-Michael products were reduced using non-selective NaBH4/MeOH or diastereoselective (up to 92:8) SnCl4/NaBH4 conditions yielding (1R?,3S?)-3-amino-1,4-diols in up to 97% and 70% yield respectively. The major reduction product was converted in two steps to (±)-HPA-12, which is an inhibitor of the cytosolic ceramide transporting protein.
Dodecanoic acid derivatives: Synthesis, antimicrobial evaluation and development of one-target and multi-target QSAR models
Sarova, Devinder,Kapoor, Archana,Narang, Rakesh,Judge, Vikramjeet,Narasimhan, Balasubramanian
, p. 769 - 781 (2012/05/20)
In this study a series of dodecanoic acid derivatives (1-30) were synthesized and evaluated for in vitro antimicrobial activity against the panel of Gram positive, Gram negative bacterial and fungal strains. 4-Nitro phenyl dodecanoate (4) and quinolin-8-yl dodecanoate (5) emerged as most effective antibacterial agents, and 1-(4-benzylpiperazin- 1-yl) dodecan-1-one (15) was found to be the most effective antifungal agent amongst the synthesized dodecanoic acid derivatives. Quantitative structure activity relationship (QSAR) studies performed by the development of one-target and multi-target models indicated that multitarget model was effective in describing the antimicrobial activity of dodecanoic acid derivatives as well demonstrated the importance of topological parameter, zero-order molecular connectivity index (0X). Springer Science+Business Media, LLC 2010.