195813-59-3

Basic information

• Product Name: 3-DiMethylaMino-1-(2-Methoxyphenyl)-2-propen-1-one, 95%
• Synonyms: 3-DiMethylaMino-1-(2-Methoxyphenyl)-2-propen-1-one, 95%;(E)-3-dimethylamino-1-(2-methoxyphenyl)prop-2-en-1-one
• CAS NO: 195813-59-3
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.253
• Mol File: 195813-59-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 59-63℃
• Boiling Point: 316.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.050±0.06 g/cm3(Predicted)
• PKA: 6.43±0.70(Predicted)
• CAS DataBase Reference: 3-DiMethylaMino-1-(2-Methoxyphenyl)-2-propen-1-one, 95%(CAS DataBase Reference)
• NIST Chemistry Reference: 3-DiMethylaMino-1-(2-Methoxyphenyl)-2-propen-1-one, 95%(195813-59-3)
• EPA Substance Registry System: 3-DiMethylaMino-1-(2-Methoxyphenyl)-2-propen-1-one, 95%(195813-59-3)

Safety Data

• Hazardous Substances Data: 195813-59-3(Hazardous Substances Data)

Usage

Description

3-DiMethylaMino-1-(2-Methoxyphenyl)-2-propen-1-one, 95% is an organic compound with the chemical formula C12H13NO2. It is a derivative of chalcones, which are known for their diverse range of biological activities and applications in various fields. 3-DiMethylaMino-1-(2-Methoxyphenyl)-2-propen-1-one, 95% is characterized by its 95% purity, indicating a high level of quality and consistency in its composition.

Uses

Used in Pharmaceutical Industry:
3-DiMethylaMino-1-(2-Methoxyphenyl)-2-propen-1-one, 95% is used as a reactant for the preparation of Dihydroimidazopyrimidinamines. These compounds are of significant interest in the pharmaceutical industry due to their potential therapeutic applications, particularly as inhibitors of various enzymes and receptors involved in disease processes.
3-DiMethylaMino-1-(2-Methoxyphenyl)-2-propen-1-one, 95% is also used as a reactant in the synthesis of Isoflavones. Isoflavones are a class of naturally occurring compounds found in plants, which exhibit a range of biological activities, including antioxidant, anti-inflammatory, and estrogenic properties. They are widely studied for their potential health benefits and are used in the development of pharmaceuticals and nutraceuticals.
Used in Chemical Synthesis:
In the field of chemical synthesis, 3-DiMethylaMino-1-(2-Methoxyphenyl)-2-propen-1-one, 95% serves as an important building block for the creation of various complex organic molecules. Its unique structure and functional groups make it a versatile starting material for the synthesis of a wide range of compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Research and Development:
Due to its potential applications in various industries, 3-DiMethylaMino-1-(2-Methoxyphenyl)-2-propen-1-one, 95% is also utilized in research and development laboratories. Scientists and researchers use this compound to explore new reaction pathways, develop novel synthetic methods, and investigate its biological activities and potential applications in drug discovery and development.

Upstream product

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Relevant articles and documents

Harnessing Stereospecific Z-Enamides through Silver-Free Cp?Rh(III) Catalysis by Using Isoxazoles as Masked Electrophiles

The stereospecific synthesis of Z-enamides is described in this paper. For the first time, isoxazoles have been employed as electrophiles in C-H functionalization to afford thermodynamically less stable Z-enamides utilizing salicylaldehydes in an atom- and step-economic fashion. The stereochemistry of enamides might originate from the relative disposition of atoms present in isoxazole and the intramolecular hydrogen bonding. The reaction showed excellent scope as several structurally and electronically diverse salicylaldehydes and isoxazoles reacted efficiently.

Discovery and structure-activity relationships study of novel thieno[2,3-b]pyridine analogues as hepatitis C virus inhibitors

Current treatment for hepatitis C is barely satisfactory, there is an urgent need to develop novel agents for combating hepatitis C virus infection. This study discovered a new class of thieno[2,3-b]pyridine derivatives as HCV inhibitors. First, a hit compound characterized by a thienopyridine core was identified in a cell-based screening of our privileged small molecule library. And then, structure activity relationship study of the hit compound led to the discovery of several potent compounds without obvious cytotoxicity in vitro (12c, EC50 = 3.3 μM, SI >30.3, 12b, EC50 = 3.5 μM, SI >28.6, 10l, EC50 = 3.9 μM, SI >25.6, 12o, EC 50 = 4.5 μM, SI >22.2, respectively). Although the mechanism of them had not been clearly elucidated, our preliminary optimization of this class of compounds had provided us a start point to develop new anti-HCV agents.

Novel thienopyridine derivatives as specific anti-hepatocellular carcinoma (HCC) agents: Synthesis, preliminary structure-activity relationships, and in vitro biological evaluation

Novel thienopyridine derivatives 1b-1r were synthesized, based on a hit compound 1a that was found in a previous cell-based screening of anticancer drugs. Compounds 1a-1r have the following features: (1) their anticancer activity in vitro was first reported by our group. (2) The most potent analog 1g possesses hepatocellular carcinoma (HCC)-specific anticancer activity. It can specifically inhibit the proliferation of the human hepatoma HepG2 cells with an IC50 value of 0.016 μM (compared with doxorubicin as a positive control, whose IC50 was 0.37 μM). It is inactive toward a panel of five different types of human cancer cell lines. (3) Compound 1g remarkably induces G0/G1 arrest and apoptosis in HepG2 cells in vitro at low micromolar concentrations. These results, especially the HCC-specific anticancer activity of 1g, suggest their potential in targeted chemotherapy for HCC.