196703-73-8

Basic information

• Product Name: (2R,3S)-2,3-Dihydroxy-butyric acid benzyl ester
• Synonyms: (2R,3S)-2,3-Dihydroxy-butyric acid benzyl ester
• CAS NO: 196703-73-8
• Molecular Weight: 210.23
• Mol File: 196703-73-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2R,3S)-2,3-Dihydroxy-butyric acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-2,3-Dihydroxy-butyric acid benzyl ester(196703-73-8)
• EPA Substance Registry System: (2R,3S)-2,3-Dihydroxy-butyric acid benzyl ester(196703-73-8)

Safety Data

• Hazardous Substances Data: 196703-73-8(Hazardous Substances Data)

Upstream product

• 100-51-6 benzyl alcohol 
• 71338-71-1 benzyl crotonate 
• 71338-71-1 benzyl (E)-2-butenoate 

Relevant articles and documents

Scalable synthesis of enantiomerically pure syn -2,3-dihydroxybutyrate by sharpless asymmetric dihydroxylation of p -phenylbenzyl crotonate

An efficient four-step synthetic route to the useful chiral building block (2R,3S)-dihydroxybutyric acid acetonide in >95% ee is detailed. The sequence is readily scaled, requires no chromatography, and allows for efficient recycling of p-phenylbenzyl alcohol, an expedient for enantio- and diastereoenrichment by recrystallization.

Asymmetric dihydroxylation onto the α,β-unsaturated carboxylic ester derivatives of camptothecin

Dihydroxyalkanoic ester derivatives (4a,b) and (5a,b) of 20S-camptothecin (1) were diastereoselectively synthesized by exploiting osmium-catalyzed asymmetric dihydroxylation based on the Sharpless procedure. The absolute configuration of the newly formed