197151-85-2Relevant articles and documents
Development of 99mTc-labeled trivalent isonitrile radiotracer for folate receptor imaging
Lodhi, Nadeem Ahmed,Park, Ji Yong,Hong, Mi Kyung,Kim, Young Joo,Lee, Yun-Sang,Cheon, Gi Jeong,Jeong, Jae Min
, p. 1925 - 1931 (2019)
Folate receptors (FR) are frequently overexpressed in a wide variety of human cancers. The aim of this study was to develop a trivalent 99mTc(CO)3-labeled folate radiotracer containing isonitrile (CN-R) as the coordinating ligand for
Self-assembled targeted folate-conjugated eight-arm-polyethylene glycol-betulinic acid nanoparticles for co-delivery of anticancer drugs
Dai, Lin,Cao, Xin,Liu, Ke-Feng,Li, Chun-Xiao,Zhang, Gui-Feng,Deng, Li-Hong,Si, Chuan-Ling,He, Jing,Lei, Jian-Du
, p. 3754 - 3766 (2015)
In this study, a targeted nanoparticle platform for co-delivery of anticancer drugs based on folate-conjugated eight-arm-polyethylene glycol-betulinic acid (F-8arm-PEG-BA) was first presented. F-8arm-PEG-BA was synthesized by introducing target molecules
Folic acid conjugates of a bleomycin mimic for selective targeting of folate receptor positive cancer cells
Geersing, Arjan,de Vries, Reinder H.,Jansen, Gerrit,Rots, Marianne G.,Roelfes, Gerard
supporting information, p. 1922 - 1927 (2019/06/05)
A major challenge in the application of cytotoxic anti-cancer drugs is their general lack of selectivity, which often leads to systematic toxicity due to their inability to discriminate between malignant and healthy cells. A particularly promising target for selective targeting are the folate receptors (FR) that are often over-expressed on cancer cells. Here, we report on a conjugate of the pentadentate nitrogen ligand N4Py to folic acid, via a cleavable disulphide linker, which shows selective cytotoxicity against folate receptor expressing cancer cells.
Synthesis of a functionalized dipeptide for targeted delivery and pH-sensitive release of chemotherapeutics
Kiran, Sonia,Dwivedi, Pankaj,Khatik, Renuka,Hameed, Sadaf,Dwivedi, Monika,Huang, Fangsheng,Xu, Ronald X.
, p. 285 - 288 (2019/12/30)
Targeted delivery of chemotherapeutics to tumor cells is one of the biggest challenges in cancer treatment. Herein, we synthesized smart dipeptide nanoparticles for cancer-specific targeting and intracellular pH-sensitive release of chemotherapeutics. Diphenylalanine peptide was synthesized and further developed as nanoparticles (NPs), which were functionalized with folic acid utilizing the carbodiimide reaction. Doxorubicin (Dox) was loaded to self-assembled non-functionalized (FF-Dox) and folate functionalized peptides NPs (FA-FF-Dox). Moreover, the experiments revealed the pH-sensitive release of Dox for both FA-FF-Dox and FF-Dox due to the protonation of the Schiff base and the amines present in the peptides at low pH, enhancing intracellular release subsequent to receptor-mediated endocytosis. Further, biodistribution and the pharmacokinetics study revealed enhanced targeting efficiency of FA-FF-Dox with high accumulation in tumor cells.
