197153-87-0Relevant articles and documents
Construction of self-assembled nanostructure-based tetraphenylethylene dipeptides: Supramolecular nanobelts as biomimetic hydrogels for cell adhesion and proliferation
Lin, Hsin-Chieh,Mohammed, Mohiuddin,Talloj, Satish Kumar
, p. 7483 - 7493 (2020)
Supramolecular fluorescent materials with aggregation-induced emission (AIE) characteristics have promising applications as fluorescent probes for bio and chemosensors. In this study, a versatile low molecular weight tetraphenylethylene dipeptide hydrogelator (TPE-YY) with efficient AIE characteristics was developed, which was able to form hydrogels in a broad pH range from 3.7 to 10.2. The self-assembly of this hydrogel is completely pH-dependent, with significant structural transitions from high to low pH. At a relatively high pH value (10.2), a weak transparent hydrogel with an entangled network of nanofibers was obtained, while upon neutralization (pH 7.2) with dilute HCl, a stable semi-transparent gel with twisted nanobelts was formed. When the pH of the hydrogel was reduced to below 5.7, a turbid viscous gel and precipitation appeared with the thickening of the nanobelts. Surprisingly, the hydrogel resulting from the glucono-δ-lactone triggered gel showed only nanofibers independent of pH. The nature of the hydrogels and the nanostructures at different pH values were thoroughly examined and discussed via oscillatory rheology, electron microscopy and various spectroscopic techniques {1HNMR, 2D-NMR, Fourier transform infrared (FTIR) and Circular dichroism (CD)}. Interestingly, the self-assembled hydrogel exhibited excellent biocompatibility over 95% using hydrogel leachables on two different cell lines, 3A6 (human MSCs) and L929 (mouse fibroblast cells). Moreover, the self-assembled nanobelts formed at neutral pH showed excellent cell adhesion and proliferation of 3A6 cells, whereas the nanofibers showed poor cell adhesion and proliferation. Overall, we demonstrate the importance of chemical design for the formation of self-assembled nanobelts and supramolecular hydrogels at physiological pH with selective cell adhesion and proliferation, presenting a promising applications in tissue engineering and regenerative medicine. This journal is
Specific detection of cancer cells through aggregation-induced emission of a light-up bioprobe
Chen, Jian,Jiang, Hong,Zhou, Huipeng,Hu, Zhenzhen,Niu, Niu,Shahzad, Sohail Anjum,Yu, Cong
, p. 2398 - 2401 (2017)
A cancer cell specific aptamer was labeled with an aggregation-induced emission (AIE) probe for the first time. Using it as a light-up bioprobe, a specific cancer cell detection method is developed.
Molecular luminogens based on restriction of intramolecular motions through host-guest inclusion for cell imaging
Liang, Guodong,Lam, Jacky W. Y.,Qin, Wei,Li, Jie,Xie, Ni,Tang, Ben Zhong
, p. 1725 - 1727 (2014)
We developed a new strategy to restrict the motions of AIE molecules through host-guest inclusion, affording a catalogue of new molecular luminogens.
Homogeneous probing of lipase and α-amylase simultaneously by AIEgens
Shi, Jie,Deng, Qianchun,Li, Ya,Zheng, Zhe,Shangguan, Huijuan,Li, Lu,Huang, Fenghong,Tang, Bo
, p. 6417 - 6420 (2019)
An AIE dual-reactive supramolecular probe has been devised for the first time to simultaneously measure endogenous lipase and α-amylase activity in a homogeneous system. Fluorescence quantitative analysis of lipase and α-amylase in real biological samples enables rapid and accurate diagnosis of diseases.
A mechanistic study of AIE processes of TPE luminogens: Intramolecular rotation vs. configurational isomerization
Yang, Zhiyong,Qin, Wei,Leung, Nelson L. C.,Arseneault, Mathieu,Lam, Jacky W. Y.,Liang, Guodong,Sung, Herman H. Y.,Williams, Ian D.,Tang, Ben Zhong
, p. 99 - 107 (2015)
Chromophores containing olefinic double bonds are the core components of many important luminogen systems that show the novel photophysical effect of aggregation-induced emission (AIE). The role and extent of E-Z isomerization (EZI) of the double bond in affecting the solution emissions of the AIE luminogens (AIEgens), however, have not been fully understood. In this work, we verified the occurrence of EZI in the dilute solutions of TPE-cored AIEgens by NMR spectroscopy using elaborate experimental procedures. We further designed a TPE-fluorescein adduct to quantify that EZI plays a minor role whereas intramolecular rotation plays a major role in the emission quenching processes of the AIEgen solutions. This study fills the gap in the research on the restriction of the intramolecular rotation (RIR) mechanism for the AIE effect and provides a useful tool for the mechanistic investigation of photoluminescence processes.
