197239-54-6

Basic information

• Product Name: 3-(3-FLUORO-PHENYL)-PROP-2-YN-1-OL
• Synonyms: 3-(3-FLUOROPHENYL)PRO-2-YN-1-OL;3-(3-FLUORO-PHENYL)-PROP-2-YN-1-OL;AKOS PRN-0020;2-Propyn-1-ol, 3-(3-fluorophenyl)- (9CI);3-(3-Fluorophenyl)-2-propyn-1-ol;1-(3-Fluorophenyl)-3-hydroxyprop-1-yne
• CAS NO: 197239-54-6
• Molecular Formula: C₉H₇FO
• Molecular Weight: 150.15
• Product Categories: HALIDE
• Mol File: 197239-54-6.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 247.3°Cat760mmHg
• Flash Point: 113.4°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 0.0137mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: 3-(3-FLUORO-PHENYL)-PROP-2-YN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-FLUORO-PHENYL)-PROP-2-YN-1-OL(197239-54-6)
• EPA Substance Registry System: 3-(3-FLUORO-PHENYL)-PROP-2-YN-1-OL(197239-54-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 197239-54-6(Hazardous Substances Data)

Usage

General Description

3-(3-fluoro-phenyl)-prop-2-yn-1-ol is a chemical compound with the molecular formula C9H7FO. It is an organic compound with a propargyl alcohol backbone and a fluorophenyl group attached to it. 3-(3-FLUORO-PHENYL)-PROP-2-YN-1-OL is commonly used in organic synthesis as a building block for the production of various pharmaceuticals and fine chemicals. Its unique structure and reactivity make it a valuable intermediate in the synthesis of more complex molecules. 3-(3-fluoro-phenyl)-prop-2-yn-1-ol has also been studied for its potential biological activities and has shown promise as a potential drug candidate in medicinal chemistry research.

InChI:InChI=1/C9H7FO/c10-9-5-1-3-8(7-9)4-2-6-11/h1,3,5,7,11H,6H2

Upstream product

• 1121-86-4 1-Fluoro-3-iodobenzene 
• 107-19-7 propargyl alcohol 
• 1073-06-9 3-fluorobromobenzene 
• 50-00-0 formaldehyd 
• 2561-17-3 1-ethynyl-3-fluoro-benzene 

Downstream Products

• 778549-42-1 O-[3-(3-Fluoro-phenyl)-prop-2-ynyl]-hydroxylamine 
• 1020153-64-3 1-(3-bromoprop-1-yn-1-yl)-3-fluorobenzene 
• 1197397-25-3 (Z)-3-(3-fluorophenyl)prop-2-en-1-ol 
• 125872-67-5 (E)-3-(3-fluorophenyl)prop-2-en-1-ol 
• 1197397-21-9 3-(3-fluorophenyl)propiolaldehyde 

Relevant articles and documents

Bi(OTf)3-catalyed One-pot Synthesis of α-Halo-β-amino Ketones and Acyl Aziridines from 3-Aryl Propargyl Alcohols

A Bi(OTf)3-catalyed reaction of 3-aryl propargyl alcohols with sulfonamide and halogen source was firstly investigated, which provided a facile route for the synthesis of a large variety of α-halo-β-amino ketones. The key intermediates, β-amino

Catalyst-Free Annulation of 2-Pyridylacetates and Ynals with Molecular Oxygen: An Access to 3-Acylated Indolizines

A catalyst and additive-free annulation of 2-pyridylacetates and ynals under molecular oxygen was the first developed, affording 3-acylated indolizines in good to excellent yields. Molecular oxygen was used as the source of the carbonyl oxygen atom in indolizines. This approach was compatible with a wide range of functional groups, and especially it has been successfully extended to unsaturated double bonds and triple bonds, which were difficult to prepare by previous methods in a single step.

Applications of Thermal Activation, Ball-milling and Aqueous Medium in Stereoselective Michael Addition of Nitromethane to Enynones Catalyzed by Chiral Squaramides

Stereoselective addition of nitromethane to conjugated en-ynones was performed through the application of chiral squaramides. Three non-classical approaches to promote the addition reaction were tested, including activation of the nucleophile by inorganic base in a biphasic aqueous system, thermal activation, and ball-milling. Hydrogen-bonding catalysis was effective in all these methods, providing 1,4-addition products in high yields and stereoselectivities of up to 98% requiring 1–5 mol% of Cinchona alkaloid squaramide. (Figure presented.).