19733-56-3

Basic information

• Product Name: 4-piperidin-3-ylaniline
• Synonyms: 4-piperidin-3-ylaniline;4-Piperidin-3-yl-phenylamine;Benzenamine, 4-(3-piperidinyl)-
• CAS NO: 19733-56-3
• Molecular Formula: C₁₁H₁₆N₂
• Molecular Weight: 176
• Mol File: 19733-56-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 96-97 °C
• Boiling Point: 331.9±35.0 °C(Predicted)
• Appearance: /
• Density: 1.043±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.26±0.10(Predicted)
• CAS DataBase Reference: 4-piperidin-3-ylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-piperidin-3-ylaniline(19733-56-3)
• EPA Substance Registry System: 4-piperidin-3-ylaniline(19733-56-3)

Safety Data

• Hazardous Substances Data: 19733-56-3(Hazardous Substances Data)

Usage

Description

4-Piperidin-3-ylaniline is an organic compound that features a piperidine ring attached to an aniline group. It is characterized by its potential to form various chemical bonds and participate in complex chemical reactions, making it a versatile building block in organic synthesis.

Uses

Used in Pharmaceutical Industry:
4-Piperidin-3-ylaniline is used as a reagent for the large-scale synthesis of oral PARP inhibitors. It plays a crucial role in the development of these inhibitors, which are important for their potential therapeutic applications in treating various types of cancer. Its structural properties allow it to be incorporated into the molecular framework of PARP inhibitors, contributing to their efficacy and selectivity in targeting cancer cells.

Upstream product

• 4282-46-6 3-(4'-nitrophenyl)pyridine 
• 1692-25-7 3-pyridylboronic acid 
• 586-78-7 para-nitrophenyl bromide 
• 2945-08-6 methyl (4-nitrophenyl)acetate 
• 104-03-0 4-nitrobenzeneacetic acid 
• 40114-49-6 1-benzyl-3-piperidone 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 171364-83-3 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nitrobenzene 
• 30698-33-0 methyl 2-cyano-2-(4-nitrophenyl)acetate 
• 119023-00-6 methyl 4-cyano-4-(4-nitrophenyl)butanoate 
• 92137-91-2 3-(4-nitrophenyl)piperidine-2,6-dione 
• 19733-55-2 3-(4-nitrophenyl)piperidine 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 1196713-22-0 (3S)-3-(4-aminophenyl)piperidinium (2R,3R)-3-carboxy-2,3-dihydroxypropanoate 
• 875798-79-1 3-(4-aminophenyl)piperidine-1-carboxylic acid tert-butyl ester 
• 1038915-64-8 (3S)-3-[4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl]piperidinium chloride 
• 1171197-20-8 (3S)-3-(4-aminophenyl)piperidine-1-carboxylic acid tert-butyl ester 
• 1263284-59-8 (+)-(R)-tert-butyl 3-(4-aminophenyl)piperidine-1-carboxylate 
• 1196713-67-3 2-[4-((3S)-(tertbutoxycarbonyl)piperidin-3-yl)phenyl]-2H-indazole-7-carboxylic acid methyl ester 
• 1038916-11-8 tert-butyl (3S)-3-{4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl}piperidine-1-carboxylate 
• 1196713-21-9 (3S)-3-(4-aminophenyl)piperidine 
• 1038916-08-3 2-{4-[(3S)-1-(tert-butoxycarbonyl)piperidin-3-yl]phenyl}-2H-indazole-7-carboxylic acid 
• 1312106-32-3 18-(nitrobenzylideneamino)phenylpiperidine-1-carboxylate 
• 1038915-60-4 (3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine 

Relevant articles and documents

PROCESSES FOR THE PREPARATION OF NIRAPARIB AND INTERMEDIATES THEREOF

The present invention relates to novel procedures and novel intermediates useful in the synthesis of Niraparib or any salt thereof.

Preparation method of 4-(3-piperidino) aniline and tartrate thereof

The invention belongs to the field of organic synthesis and particularly relates to a preparation method of 4-(3-piperidino) aniline and tartrate thereof. The preparation method is characterized by comprising the following steps: taking p-nitrophenylaceti

Preparation method of niraparib intermediate 4-(piperidyl-3-yl)aniline

The invention belongs to the field of medicine synthesis, and relates to a preparation method of niraparib intermediate 4-(piperidyl-3-yl)aniline. According to the method, halogenated 1-benzyl-3-(4-nitrophenyl)pyridinium used as the initial raw material is subjected to catalytic hydrogenation in the presence of Pd/C to obtain the 4-(piperidyl-3-yl)aniline. The method has the advantages of low cost, high yield, high safety and environment friendliness, can effectively avoid the generation of the N-(4-(pyridyl-3-yl)phenyl)hydroxylamine impurity, is easy to operate and suitable for large-scale production, and provides technical supports for further preparation of high-purity niraparib.