197712-58-6Relevant articles and documents
BODIPY-based hydroxypyridyl derivative as a highly Ni2+-selective fluorescent chemosensor
Chen, Yen-Chun,Devendhiran, Tamiloli,Dong, Teng-Yuan,Huang, Po-Jui,Kumarasamy, Keerthika,Lin, Mei-Ching
, (2021)
A novel fluorescent chemosensor based on BODIPY-NO2 was synthesized and characterized by NMR, MALDI-MS, UV-Vis and fluorescence spectrum. Also, the single-crystal structure of BODIPY-NO2 was determined by X-ray crystallography. The chemosensor shows selective “turn-off” fluorescence response to Ni2+ ion over various other competing metal ions such as Li+, K+, Ca2+, Mg2+, Hg2+, Cu2+, Zn2+, Cd2+ and Mn2+ in CH3CN solution. The BODIPY-NO2 showed a visible absorption band at 502 nm with a shoulder at the shorter wavelength side. The fluorescence emission band was observed at 543 nm of the sensor in the presence of Ni2+ ion with high quantum yield (Φ: 0.39). The square planar [Ni(BODIPY-NO2)(CH3CN)] metal center acts as an efficient quencher for the excited-state based on electron-transfer processes. The BODIPY-NO2 to Ni2+ sensitive nature was determined from the limit of detection 1.7 × 10?7 M in fluorescence emission. The chemosensor BODIPY-NO2 binds to Ni2+ in a 1:1 molar ratio calculated by the job's plot and the binding constant is determined to be 3.1 × 105 M?1. The fluorescence quenching occurred in an acid condition, using the titration experiment with pH 1.0–4.0.
Structure-activity relationship study of BACE1 inhibitors possessing a chelidonic or 2,6-pyridinedicarboxylic scaffold at the P2 position
Hamada, Yoshio,Suzuki, Kenji,Nakanishi, Tomoya,Sarma, Diganta,Ohta, Hiroko,Yamaguchi, Ryoji,Yamasaki, Moe,Hidaka, Koushi,Ishiura, Shoichi,Kiso, Yoshiaki
, p. 618 - 623 (2014/01/23)
We have previously reported potent substrate-based pentapeptidic BACE1 inhibitors possessing a hydroxymethylcarbonyl isostere as a substrate transition-state mimic. While these inhibitors exhibited potent activities in enzymatic and cellular assays (KMI-4
