1978-06-9 Usage
Description
2,3-BIS(TRIFLUOROMETHYL)NITROBENZENE, with the chemical formula C7H3F6NO2, is a nitroaromatic compound characterized by the presence of two trifluoromethyl groups at the 2 and 3 positions on the benzene ring. It is recognized for its strong electron-withdrawing properties and unique physical and chemical attributes conferred by the trifluoromethyl groups, positioning it as a significant reagent in organic chemistry.
Uses
Used in Pharmaceutical Industry:
2,3-BIS(TRIFLUOROMETHYL)NITROBENZENE is utilized as a key building block in the synthesis of pharmaceuticals, owing to its ability to enhance the activity and selectivity of drug molecules. Its electron-withdrawing nature and trifluoromethyl groups contribute to the development of novel therapeutic agents with improved pharmacokinetic and pharmacodynamic profiles.
Used in Agrochemical Industry:
In the agrochemical sector, 2,3-BIS(TRIFLUOROMETHYL)NITROBENZENE serves as a crucial intermediate for the production of various agrochemicals. Its unique properties allow for the creation of compounds with enhanced pesticidal activity and selectivity, contributing to more effective and targeted crop protection solutions.
Used in Materials Science:
2,3-BIS(TRIFLUOROMETHYL)NITROBENZENE is employed as a component in the development of advanced materials, capitalizing on its electron-withdrawing properties and trifluoromethyl groups to engineer materials with specific characteristics. These materials find applications in various fields, including electronics, coatings, and specialty chemicals.
It is imperative to handle 2,3-BIS(TRIFLUOROMETHYL)NITROBENZENE with caution due to its hazardous nature, as it can cause skin and eye irritation. Proper safety measures should be implemented during its use to mitigate potential risks.
Check Digit Verification of cas no
The CAS Registry Mumber 1978-06-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,7 and 8 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1978-06:
(6*1)+(5*9)+(4*7)+(3*8)+(2*0)+(1*6)=109
109 % 10 = 9
So 1978-06-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H3F6NO2/c9-7(10,11)4-2-1-3-5(15(16)17)6(4)8(12,13)14/h1-3H
1978-06-9Relevant articles and documents
Structure-activity relationships of antitubercular salicylanilides consistent with disruption of the proton gradient via proton shuttling
Lee, Ill-Young,Gruber, Todd D.,Samuels, Amanda,Yun, Minhan,Nam, Bora,Kang, Minseo,Crowley, Kathryn,Winterroth, Benjamin,Boshoff, Helena I.,Barry III, Clifton E.
, p. 114 - 126 (2013/02/22)
A series of salicylanilides was synthesized based on a high-throughput screening hit against Mycobacterium tuberculosis. A free phenolic hydroxyl on the salicylic acid moeity is required for activity, and the structure-activity relationship of the aniline ring is largely driven by the presence of electron withdrawing groups. We synthesized 94 analogs exploring substitutions of both rings and the linker region in this series and we have identified multiple compounds with low micromolar potency. Unfortunately, cytotoxicity in a murine macrophage cell line trends with antimicrobial activity, suggesting a similar mechanism of action. We propose that salicylanilides function as proton shuttles that kill cells by destroying the cellular proton gradient, limiting their utility as potential therapeutics.
