19797-08-1

Basic information

• Product Name: 1-Ethylhexahydro-2H-azepine-2-one
• Synonyms: 1-Ethylhexahydro-2H-azepine-2-one;Hexahydro-1-ethyl-2H-azepin-2-one;N-Ethyl-ε-caprolactam
• CAS NO: 19797-08-1
• Molecular Formula: C₈H₁₅NO
• Molecular Weight: 141.21
• Mol File: 19797-08-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 249°C at 760 mmHg
• Flash Point: 105°C
• Appearance: /
• Density: 0.945g/cm³
• Vapor Pressure: 0.0235mmHg at 25°C
• Refractive Index: 1.457
• CAS DataBase Reference: 1-Ethylhexahydro-2H-azepine-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Ethylhexahydro-2H-azepine-2-one(19797-08-1)
• EPA Substance Registry System: 1-Ethylhexahydro-2H-azepine-2-one(19797-08-1)

Safety Data

• Hazardous Substances Data: 19797-08-1(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Faint

Molecular structure

Cyclic organic compound

Applications

a. Intermediate in the production of pharmaceuticals
b. Intermediate in the production of fragrances
c. Intermediate in the production of other organic compounds

Industrial use

Solvent in various processes

Stability

Versatile chemical with diverse applications

Low toxicity

Suitable for use in various industries

Compatibility

Compatible with other compounds

InChI:InChI=1/C8H15NO/c1-2-9-7-5-3-4-6-8(9)10/h2-7H2,1H3

Upstream product

• 105-60-2 caprolactam 
• 64-17-5 ethanol 
• 13414-33-0 7-ethoxy-3,4,5,6-tetrahydro-2H-azepine 
• 74-96-4 ethyl bromide 
• 2235-00-9 vinylcaprolactam 
• 74-85-1 ethene 
• 515-46-8 Ethyl benzenesulfonate 
• 3553-94-4 1-trimethylsilanyl-azepan-2-one 
• 75-07-0 acetaldehyde 

Downstream Products

• 87143-86-0 1-Ethyl-2-phenylethynyl-azepane 
• 87143-87-1 2,2-bis(phenylethynyl)-1-ethylperhydroazepine 
• 1888-91-1 N-acetylcaprolactam 
• 89732-95-6 1-ethylhexahydro-2H-azepin-2,7-dione 

Relevant articles and documents

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PROCESS FOR THE SYNTHESIS OF N-SUBSTITUTED LACTAMS AND AMIDES

A process for the synthesis of N-alkylated lactams via reductive alkylation. The process of the present disclosure may be conducted by the addition of an aldehyde to a lactam in the presence of a catalyst under a reducing atmosphere.

Chemoselective Hydrogenation of Olefins Using a Nanostructured Nickel Catalyst

The selective hydrogenation of functionalized olefins is of great importance in the chemical and pharmaceutical industry. Here, we report on a nanostructured nickel catalyst that enables the selective hydrogenation of purely aliphatic and functionalized olefins under mild conditions. The earth-abundant metal catalyst allows the selective hydrogenation of sterically protected olefins and further tolerates functional groups such as carbonyls, esters, ethers and nitriles. The characterization of our catalyst revealed the formation of surface oxidized metallic nickel nanoparticles stabilized by a N-doped carbon layer on the active carbon support.

Environmentally responsible, safe, and chemoselective catalytic hydrogenation of olefins: ppm level Pd catalysis in recyclable water at room temperature

Textbook catalytic hydrogenations are typically presented as reactions done in organic solvents and oftentimes under varying pressures of hydrogen using specialized equipment. Catalysts new and old are all used under similar conditions that no longer reflect the times. By definition, such reactions are both environmentally irresponsible and dangerous, especially at industrial scales. We now report on a general method for chemoselective and safe hydrogenation of olefins in water using ppm loadings of palladium from commercially available, inexpensive, and recyclable Pd/C, together with hydrogen gas utilized at 1 atmosphere. A variety of alkenes is amenable to reduction, including terminal, highly substituted internal, and variously conjugated arrays. In most cases, only 500 ppm of heterogeneous Pd/C is sufficient, enabled by micellar catalysis used in recyclable water at room temperature. Comparison with several newly introduced catalysts featuring base metals illustrates the superiority of chemistry in water.