198198-50-4

Basic information

• Product Name: (2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester
• Synonyms: (2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester
• CAS NO: 198198-50-4
• Molecular Weight: 379.572
• Mol File: 198198-50-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester(198198-50-4)
• EPA Substance Registry System: (2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester(198198-50-4)

Safety Data

• Hazardous Substances Data: 198198-50-4(Hazardous Substances Data)

Upstream product

• 53067-23-5 methyl 7-methyl-3-oxooct-6-enoate 
• 175857-84-8 methyl (2R,3R)-2-(1,2-bis(tert-butoxycarbonyl)hydrazino)-3-[(tert-butyldimethylsilyl)oxy]-6-(mesyloxy)hexanoate 
• 198198-48-0 methyl (2R,3R)-2-(1,2-bis(tert-butoxycarbonyl)hydrazino)-3-[(tert-butyldimethylsilyl)oxy]-7-methyloct-6-enoate 
• 175857-83-7 methyl (2R,3R)-2-(1,2-bis(tert-butoxycarbonyl)hydrazino)-3-hydroxy-7-methyloct-6-enoate 
• 175857-85-9 (2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-piperidine-2-carboxylic acid methyl ester 
• 87894-26-6 (R)-(-)-3-hydroxy-7-methyl-6-octenoic acid methyl ester 
• 198198-49-1 (2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 

Downstream Products

• 198198-52-6 (2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-((1S,2S)-1,2-dihydroxy-2-methoxycarbonyl-ethyl)-piperidine-1-carboxylic acid benzyl ester 
• 198198-51-5 (2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-((Z)-2-methoxycarbonyl-vinyl)-piperidine-1-carboxylic acid benzyl ester 
• 85624-09-5 (3aR,9R,9aR,9bS)-octahydro-2,2-dimethyl-[1,3]dioxolo[4,5-a]indolizin-9-ol 
• 72741-87-8 swainsonine 
• 198198-55-9 (2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-formyl-piperidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

Stereocontrolled Synthesis of trans-3-Hydroxypipecolic Acids and Application to (-)-Swainsonine

The enantioselective synthesis of both enantiomers of trans-3-hydroxypipecolic acid are described from a prochiral starting material: the methyl 3-oxo-7-methyloct-6-enoate.The stereocenters of the piperidine ring are created by enantioselective hydrogenation of the β-ketoester and by diastereoselective electrophilic amination of the β-hydroxyester enolate. (2R,3R)-3-Hydroxypipecolic acid methyl ester is the precursor for the synthesis of (-)-swainsonine. - Keywords: piperidine; indolizidine; chiral ruthenium complex; electrophilic amination.