19858-02-7

Basic information

• Product Name: 2H-Azepin-2-one, hexahydro-1-phenyl-
• Synonyms: N-Phenyl hexane lactame-6;1-phenyl-azepan-2-one;hexahydro-1-phenyl-2H-azepin-2-one;1-phenyl-2-azepanone;2H-Azepin-2-one,hexahydro-1-phenyl
• CAS NO: 19858-02-7
• Molecular Formula: C12H15NO
• Molecular Weight: 189.257
• Mol File: 19858-02-7.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: 2H-Azepin-2-one, hexahydro-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Azepin-2-one, hexahydro-1-phenyl-(19858-02-7)
• EPA Substance Registry System: 2H-Azepin-2-one, hexahydro-1-phenyl-(19858-02-7)

Safety Data

• Hazardous Substances Data: 19858-02-7(Hazardous Substances Data)

Usage

Class

Azepine derivative

Uses

Pharmaceutical industry for drug synthesis

Structure

Cyclic amide with a hexahydro-1-phenylazepine core

Properties

Versatile building block for new medications

Therapeutic applications

Central nervous system disorders, potential anti-inflammatory agent

Enzyme inhibition

Potential inhibitor for certain enzymes

Organic synthesis

Applications in the field of organic synthesis

Upstream product

• 40832-99-3 N-phenylazepane 
• 105-60-2 caprolactam 
• 108-95-2 phenol 
• 538-51-2 benzylidene phenylamine 
• 103-84-4 Acetanilid 
• 626-86-8 adipinic acid monoethyl ester 
• 62-53-3 aniline 
• 124-04-9 Adipic acid 
• 20270-53-5 di-tert-butyl 1,6-hexanedioate 
• 22809-37-6 6-bromohexanoyl chloride 
• 98-80-6 phenylboronic acid 
• 108-90-7 chlorobenzene 
• 108-86-1 bromobenzene 
• 603-33-8 triphenylbismuthane 

Downstream Products

• 84447-34-7 6-(phenylamino)hexan-1-ol 
• 40832-99-3 N-phenylazepane 
• 1402844-82-9 7-(1H-benzo[d]imidazol-1-yl)-1-phenylazepan-2-one 
• 62386-20-3 1-(4-chloro-phenyl)-hexahydro-azepin-2-one 
• 280120-09-4 N-[4-bromophenyl]caprolactam 

Relevant articles and documents

Metalloporphyrin-catalysed rearrangement of oxaziridines: An efficient and regioselective synthesis of lactams using ring-enlargement of N-phenyl-spirooxaziridines

Manganese(III) tetraphenylporphyrin, Mn(tpp)Cl, is a new and specific catalyst for stereo- and regio-selective rearrangement of N-phenyl-spirooxaziridines into lactams.

A new synthesis of N-phenyl lactams

The synthesis of N-phenyl lactams by phase transfer oxidation of N,N- (polymethylene) anilines with potassium permanganate is reported.

Ruthenium-Pincer-Catalyzed Hydrogenation of Lactams to Amino Alcohols

By using the commercially available ruthenium pincer complex (Ru-MACHO-BH) as a catalyst, the challenging direct hydrogenation of lactams and analogues has been successfully accomplished to deliver corresponding value-added amino alcohols in good-to-excellent yields under mild reaction conditions. Remarkably, in addition to N-protected lactams, unprotected ones could also be readily reduced in the presence of a catalytic amount of weak base or even under neutral reaction conditions, which further highlights the broad substrate scope and the protocol efficiency.

Copper(II) incorporated functionalized polystyrene catalyzed: N -arylation of amides under solvent free condition with broad substrate scope

We demonstrate here, a new polystyrene supported Cu(ii) catalyzed proficient synthetic methodology for the facile N-arylation of aromatic, aliphatic, cyclic and heterocyclic amides with aryl halides under neat conditions. The catalyst, PS-Cu(ii)-ala, was prepared through the grafting of copper metal on a polystyrene-β-alanine imine network. The catalyst shows a wide range of substrate scope and excellent functional group tolerance, and produces the desired anilides in mostly high yields. The material is thoroughly characterized by DRS-UV, FT-IR, AAS, FE-SEM, TGA analysis and energy dispersive X-ray (EDX) studies. The catalyst can be easily recovered from the reaction medium and reused without significant loss of its catalytic activity suggesting future potential of this catalyst.