1990-29-0 Usage
Description
D-Altrose is an aldohexose that is isomeric with glucose, tallose, and allose. It is a white to off-white powder and has recently been discovered to possess antioxidant properties. This is due to its ability to suppress the production of reactive oxygen species in mitochondria through competition with D-glucose at the cellular level.
Uses
Used in Pharmaceutical Industry:
D-Altrose is used as a pharmaceutical compound for its antioxidant properties. It helps in the suppression of reactive oxygen species production in mitochondria, which can be beneficial in the development of treatments for various diseases and conditions associated with oxidative stress.
Used in Research and Development:
D-Altrose is used as a research compound for studying its isomeric properties and potential applications in various fields, including pharmaceuticals, biochemistry, and material science. Its unique properties and competition with D-glucose at the cellular level make it an interesting subject for further investigation and potential development of new drugs or therapies.
Used in Biochemical Applications:
D-Altrose is used as a biochemical compound for understanding its role in cellular processes and its potential as a therapeutic agent. Its ability to compete with D-glucose at the cellular level and its antioxidant properties make it a valuable tool for studying metabolic pathways and the development of new treatments for various diseases.
Purification Methods
Crystallise D-altrose from aqueous EtOH. If it is obtained by the hydrolysis of the acetate, then it may contain sodium and acetate ions. Ions are best removed by dissolving in H2O, passing through suitable columns of ion-exchange resins, e.g. Amberlite IR-120 and Duolite A, and concentrating in a vacuum to a syrup. This is dissolved in MeOH, filtered and evaporated in a vacuum desiccator over granular CaCl2. The thick syrup is inoculated with seed crystals, stirred, and before it sets to a magma of crystals, transfer the crystals with MeOH to a Büchner funnel. Recrystallise them in the same way. -D-Altrofuranoside has initial [] D ~-69o (c 4, H2O) which mutarotates to +33o. [Richtmeyer Methods in Carbohydrate Chemistry I 107 Academic Press 1962, Beilstein 1 IV 4301, see Angyal Adv Carbohydrate Chem Biochem 42 15 1984 for ratio of anomers in solution.]
Check Digit Verification of cas no
The CAS Registry Mumber 1990-29-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,9 and 0 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1990-29:
(6*1)+(5*9)+(4*9)+(3*0)+(2*2)+(1*9)=100
100 % 10 = 0
So 1990-29-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4-,5+,6+/m1/s1
1990-29-0Relevant articles and documents
Isolation and structures of virescenosides from the marine-derived fungus Acremonium striatisporum
Afiyatullov, Shamil Sh.,Kalinovsky, Anatoly I.,Antonov, Alexandr S.,Zhuravleva, Olesya I.,Khudyakova, Yuliya V.,Aminin, Dmitry L.,Yurchenko, Anton N.,Pivkin, Mikhail V.
, p. 66 - 71 (2016)
Four new diterpene glycosides, virescenosides R1 (1), R2 (2), R3 (3) and Z (4) were isolated from a marine strain of Acremonium striatisporum KMM 4401 associated with the holothurian Eupentacta fraudatrix. Structures of 1-3 were determined as the corresponding biosides having isopimaradiene-type aglycons with additional oxidation and unsaturation patterns. Virescenosides Z (4) was structurally identified as altroside, containing 7-en-6-one group in the tricyclic aglycon moiety. The compounds 1-4 were examined for inhibition of non-specific esterase activity in mouse lymphocytes.
Orthogonal Active-Site Labels for Mixed-Linkage endo-β-Glucanases
Jain, Namrata,Tamura, Kazune,Déjean, Guillaume,Van Petegem, Filip,Brumer, Harry
, p. 1968 - 1984 (2021/05/26)
Small molecule irreversible inhibitors are valuable tools for determining catalytically important active-site residues and revealing key details of the specificity, structure, and function of glycoside hydrolases (GHs). β-glucans that contain backbone β(1,3) linkages are widespread in nature, e.g., mixed-linkage β(1,3)/β(1,4)-glucans in the cell walls of higher plants and β(1,3)glucans in yeasts and algae. Commensurate with this ubiquity, a large diversity of mixed-linkage endoglucanases (MLGases, EC 3.2.1.73) and endo-β(1,3)-glucanases (laminarinases, EC 3.2.1.39 and EC 3.2.1.6) have evolved to specifically hydrolyze these polysaccharides, respectively, in environmental niches including the human gut. To facilitate biochemical and structural analysis of these GHs, with a focus on MLGases, we present here the facile chemo-enzymatic synthesis of a library of active-site-directed enzyme inhibitors based on mixed-linkage oligosaccharide scaffolds and N-bromoacetylglycosylamine or 2-fluoro-2-deoxyglycoside warheads. The effectiveness and irreversibility of these inhibitors were tested with exemplar MLGases and an endo-β(1,3)-glucanase. Notably, determination of inhibitor-bound crystal structures of a human-gut microbial MLGase from Glycoside Hydrolase Family 16 revealed.
Formation of Chiral Structures in Photoinitiated Formose Reaction
Stovbun,Skoblin,Zanin,Tverdislov,Taran,Parmon
, p. 108 - 116 (2018/04/05)
The possibility to synthesize biologically important sugars and other chiral compounds without any initiators in the UV-initiated reaction of formaldehyde in aqueous solution has been shown for the first time. An optically active condensed phase due to an
