199117-07-2Relevant articles and documents
Scalable, Stereocontrolled Formal Syntheses of (+)-Isoschizandrin and (+)-Steganone: Development and Applications of Palladium(II)-Catalyzed Atroposelective C?H Alkynylation
Liao, Gang,Yao, Qi-Jun,Zhang, Zhuo-Zhuo,Wu, Yong-Jie,Huang, Dan-Ying,Shi, Bing-Feng
supporting information, p. 3661 - 3665 (2018/03/05)
Dibenzocyclooctadiene lignans are an interesting class of molecules because of their unique structure based on an axially chiral biaryl moiety as well as their significant biological activity. Herein, we describe the development of a palladium-catalyzed atroposelective C?H alkynylation and its application in gram-scale, stereocontrolled formal syntheses of (+)-isoschizandrin and (+)-steganone. tert-Leucine was identified as an efficient, catalytic transient chiral auxiliary. A wide range of enantiomerically enriched biaryl compounds were prepared by this approach in good yields (up to 99 %) with excellent enantioselectivity (up to >99 % ee).
Microwave-assisted suzuki cross-coupling reaction, a key step in the synthesis of polycyclic aromatic hydrocarbons and their metabolites
Sharma, Arun K.,Gowdahalli, Krishnegowda,Krzeminski, Jacek,Amin, Shantu
, p. 8987 - 8989 (2008/03/12)
(Chemical Equation Presented) A highly efficient and general method for Suzuki cross-coupling reaction en route to the synthesis of polycyclic aromatic hydrocarbons (PAHs) and their metabolites has been developed. Microwave irradiation of aryl bromides 1
