199728-08-0

Basic information

• Product Name: 4-Chloro-2-methyl-5-nitro-6-(2-(trifluoromethyl)phenyl)-pyrimidine
• Synonyms: 4-Chloro-2-methyl-5-nitro-6-(2-(trifluoromethyl)phenyl)-pyrimidine
• CAS NO: 199728-08-0
• Molecular Weight: 317.655
• Mol File: 199728-08-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-Chloro-2-methyl-5-nitro-6-(2-(trifluoromethyl)phenyl)-pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-methyl-5-nitro-6-(2-(trifluoromethyl)phenyl)-pyrimidine(199728-08-0)
• EPA Substance Registry System: 4-Chloro-2-methyl-5-nitro-6-(2-(trifluoromethyl)phenyl)-pyrimidine(199728-08-0)

Safety Data

• Hazardous Substances Data: 199728-08-0(Hazardous Substances Data)

Upstream product

• 392-83-6 o-trifluoromethylphenyl bromide 
• 13162-43-1 4,6-dichloro-2-methyl-5-nitropyrimidine 
• 1423-27-4 2-(trifluoromethyl)phenylboronic acid 
• 497-19-8 sodium carbonate 

Downstream Products

• 219840-76-3 9-(2-Bromo-4,6-dimethoxyphenyl)-7,9-dihydro-2-methyl-6-(2-(trifluoromethyl)phenyl)-8H-purin-8-one 
• 219840-94-5 5-Amino-4-(2-bromo-4,6-dimethoxyphenyl)amino-2-methyl-6-(2-(trifluoromethyl)phenyl)-pyrimidine 
• 219840-93-4 4-(2-Bromo-4,6-dimethoxyphenyl)amino-2-methyl-5-nitro-6-(2-(trifluoromethyl)phenyl)pyrimidine 

Relevant articles and documents

Aryl- and arylamino- substituted heterocycles as corticotropin releasing hormone antagonists

Corticotropin releasing factor (CRF) antagonists of formula I: and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress in mammals.

Use of the Suzuki reaction for the synthesis of aryl-substituted heterocycles as corticotropin-releasing hormone (CRH) antagonists

The Suzuki reaction has been used to synthesize a variety of aryl- substituted heterocyclic antagonists of the CRH1 receptor. Examples with several different heterocyclic cores are potent CRH receptor ligands.