20028-40-4 Usage
Description
(1-METHYL-1H-BENZIMIDAZOL-2-YL)METHYLAMINE, also known as 1-Methyl-2-benzimidazolemethanamine, is an organic compound with a unique chemical structure that features a benzimidazole core and a methylamine side chain. (1-METHYL-1H-BENZIMIDAZOL-2-YL)METHYLAMINE has demonstrated significant biological activity, making it a promising candidate for pharmaceutical applications.
Used in Pharmaceutical Industry:
(1-METHYL-1H-BENZIMIDAZOL-2-YL)METHYLAMINE is used as an anti-cancer agent for its ability to inhibit the binding of p34 protein to NEDD4-1 protein, which plays a crucial role in the regulation of cell cycle progression and apoptosis. This inhibition can lead to the suppression of tumor growth and the prevention of cancer progression.
Additionally, (1-METHYL-1H-BENZIMIDAZOL-2-YL)METHYLAMINE is used as an HIV integrase inhibitor, which can help in the development of antiretroviral drugs. By targeting the integrase enzyme, this compound can potentially disrupt the integration of the HIV virus into the host genome, thereby limiting the virus's ability to replicate and spread within the body. This makes it a valuable asset in the ongoing fight against HIV/AIDS and related diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 20028-40-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,0,2 and 8 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 20028-40:
(7*2)+(6*0)+(5*0)+(4*2)+(3*8)+(2*4)+(1*0)=54
54 % 10 = 4
So 20028-40-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H11N3/c1-12-8-5-3-2-4-7(8)11-9(12)6-10/h2-5H,6,10H2,1H3/p+1
20028-40-4Relevant articles and documents
1-METHYL-2-BENZIMIDAZOLYLCARBENE. REACTION OF 1-METHYL-2-(CHLOROMETHYL)BENZIMIDAZOLE WITH NUCLEOPHILES
Popov, I. I.
, p. 1192 (1989)
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CHEMICAL COMPOUNDS AS ANTIBIOTICS
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Page/Page column 93, (2018/10/19)
The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R1, R2, R3, n, R4, p? q, L, ?, X and m are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics. The compounds can also be used in vitro, for example in cleaning compositions.
BENZIMIDAZOLE COMPOUNDS THAT ARE VITRONECTIN RECEPTOR ANTAGONISTS
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Page/Page column 37, (2008/06/13)
The present invention provides compounds having formula (I) wherein n, p, q and r are each independently selected from 0 or 1; a, b, c, and d each independently represents a carbon or nitrogen atom, with the proviso that no more than two of a, b, c, and d are nitrogen atoms; Y and Y' each independently represents 1-4 optional substituents selected from alkyl, alkoxy, halo, -CF3, and -C(O)OH; R, R, R and R are H or specified substituents; R, R, R, R, R, R, R and R are independently selected from H or C1-C3 alkyl; or a biolabile ester thereof, or a pharmaceutically acceptable salt thereof. Also provided are methods of using these compounds for treating vitronectin-mediated disorders, e.g., cancer, retinopathy, artherosclerosis, vascular restenosis, and osteoporosis.
