2006-80-6Relevant articles and documents
Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph3P-I2
Phakhodee, Wong,Wangngae, Sirilak,Pattarawarapan, Mookda
, p. 8058 - 8066 (2017/08/14)
Readily available N-substituted amides or their requisite carboxylic acids or acid chlorides have been used to construct 2,3-disubstituted-3H-quinazolin-4-ones in a one-pot procedure. Key transformation in this convergent approach involves Ph3P-I2-mediated formation of amidine upon condensation of an amide or the intermediate amide with methyl anthranilate. Cyclization of the amidine-tethered anthranilate then affords 2,3-disubstituted-3H-quinazolin-4-ones in good to excellent yields under mild conditions.
Efficient syntheses of 2,3-disubstituted natural quinazolinones via iridium catalysis
Fang, Jie,Zhou, Jianguang
, p. 2389 - 2391 (2012/04/11)
Natural products sclerotigenin, pegamine, deoxyvasicinone, mackinazolinone, and rutaecarpine were synthesized. Core quinazolinone structures were constructed via Ir catalysis. The Royal Society of Chemistry 2012.
Potential biologically active agents: VIII. Synthesis of 2 methyl (and styryl) 3 aryl 4 (3H) quinazolones
Varma
, p. 344 - 347 (2007/10/08)
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