2010-13-1

Basic information

• Product Name: (3-MethylaMinopropyl)-5H-dibenz[b,f]azepine
• Synonyms: (3-MethylaMinopropyl)-5H-dibenz[b,f]azepine;3-benzo[b][1]benzazepin-11-yl-N-methylpropan-1-amine
• CAS NO: 2010-13-1
• Molecular Formula: C18H20N2
• Molecular Weight: 264.3648
• Product Categories: Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 2010-13-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• CAS DataBase Reference: (3-MethylaMinopropyl)-5H-dibenz[b,f]azepine(CAS DataBase Reference)
• NIST Chemistry Reference: (3-MethylaMinopropyl)-5H-dibenz[b,f]azepine(2010-13-1)
• EPA Substance Registry System: (3-MethylaMinopropyl)-5H-dibenz[b,f]azepine(2010-13-1)

Safety Data

• Hazardous Substances Data: 2010-13-1(Hazardous Substances Data)

Usage

Description

(3-Methylaminopropyl)-5H-dibenz[b,f]azepine is a chemical compound that is identified as an impurity in Desipramine, a tricyclic antidepressant medication. It is structurally related to Imipramine, another antidepressant drug, and has the ability to inhibit the uptake of 5-hydroxytryptamine (5-HT) by human platelets in vitro.

Uses

Used in Pharmaceutical Industry:
(3-Methylaminopropyl)-5H-dibenz[b,f]azepine is used as an impurity in the production of Desipramine, a tricyclic antidepressant. Its presence is significant due to its structural similarity to Imipramine, which allows it to potentially contribute to the overall efficacy of the medication by inhibiting the uptake of 5-hydroxytryptamine (5-HT) by human platelets.
Additionally, understanding the properties and effects of this compound can be valuable for researchers and pharmaceutical companies in the development of new antidepressant medications or in refining the manufacturing processes of existing ones to minimize impurities and improve the safety and efficacy of the drugs.

Upstream product

• 1262142-19-7 N-(3-(5H-dibenzo[b,f]azepin-5-yl)propyl)acetamide 
• 50-00-0 formaldehyd 
• 2064-34-8 3-(5H-dibenzo[b,f]azepin-5-yl)propan-1-amine 

Relevant articles and documents

A Focused Library of Psychotropic Analogues with Neuroprotective and Neuroregenerative Potential

Overcoming the lack of effective treatments and the continuous clinical trial failures in neurodegenerative drug discovery might require a shift from the prevailing paradigm targeting pathogenesis to the one targeting simultaneously neuroprotection and neuroregeneration. In the studies reported herein, we sought to identify small molecules that might exert neuroprotective and neuroregenerative potential as tools against neurodegenerative diseases. In doing so, we started from the reported neuroprotective/neuroregenerative mechanisms of psychotropic drugs featuring a tricyclic alkylamine scaffold. Thus, we designed a focused-chemical library of 36 entries aimed at exploring the structural requirements for efficient neuroprotective/neuroregenerative cellular activity, without the manifestation of toxicity. To this aim, we developed a synthetic protocol, which overcame the limited applicability of previously reported procedures. Next, we evaluated the synthesized compounds through a phenotypic screening pipeline, based on primary neuronal systems. Phenothiazine 2Bc showed improved neuroregenerative and neuroprotective properties with respect to reference drug desipramine (2Aa). Importantly, we have also shown that 2Bc outperformed currently available drugs in cell models of Alzheimer's and Parkinson's diseases and attenuates microglial activation by reducing iNOS expression.