201004-29-7

Basic information

• Product Name: FMOC-LYS(ME3)-OH HCL
• Synonyms: FMOC-LYSINE(ME)3-OH CHLORIDE;FMOC-LYS(ME)3-OH CHLORIDE;FMOC-LYS(ME3)-OH HCL;FMOC-N-EPSILON-(TRIMETHYL)-L-LYSINE CHLORIDE;FMOC-L-LYS(ME3)-OH CL;N-ALPHA-FMOC-N-EPSILON,EPSILON,EPSILON-TRIMETHYL-L-LYSINE CHLORIDE;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-EPSILON-TRIMETHYLAMONIUM-L-LYSINE CHLORIDE;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-EPSILON,N-EPSILON,N-EPSILON-TRIMETHYL-L-LYSINE CHLORIDE
• CAS NO: 201004-29-7
• Molecular Formula: C24H31N2O4.Cl
• Molecular Weight: 446.97
• Product Categories: amino;amino acids
• Mol File: 201004-29-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: FMOC-LYS(ME3)-OH HCL(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-LYS(ME3)-OH HCL(201004-29-7)
• EPA Substance Registry System: FMOC-LYS(ME3)-OH HCL(201004-29-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 201004-29-7(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

Uses

Fmoc-Lys(Me)3-OH chloride is one of the common N-terminal protected reagents used in the peptide synthesis. Some of the reported examples are:Synthesis of peptide linkers for monoclonal antibody-auristatin F conjugates.Preparation of multifunctional reagents with enhanced ionization properties for the analysis of protein modification in human cells and dynamic profiling of protein lipidation.Sequential peptide ligation to synthesize histone H3 containing a trimethyl lysine residue, with modified tail region.

General Description

Fmoc protected N-trimethyl lysine

Upstream product

• 65671-53-6 N²-(tert-butoxycarbonyl)-N⁶,N⁶-dimethyl-L-lysine 
• 1395226-01-3 C₁₄H₂₉N₂O₄⁽¹⁺⁾*Cl^(1-) 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 1395226-03-5 C₉H₂₁N₂O₂⁽¹⁺⁾*C₂HF₃O₂*C₂F₃O₂^(1-) 
• 139262-23-0 9-fluorenylmethoxycarbonyl-L-alanine hydrochloride 
• 74-88-4 methyl iodide 
• 252049-10-8 Nα-Fmoc-Nε-dimethyllysine hydrochloride 

Relevant articles and documents

Development of a fluorogenic probe with a transesterification switch for detection of histone deacetylase activity

Histone deacetylases (HDACs) are key enzymatic regulators of many cellular processes such as gene expression, cell cycle, and tumorigenesis. These enzymes are attractive targets for drug development. However, very few simple methods for monitoring HDAC ac

Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition

Histone lysine methylation is regulated by N?-methyltransferases, demethylases, and N?-methyl lysine binding proteins. Thermodynamic, catalytic and computational studies were carried out to investigate the interaction of three epigen