20132-75-6

Basic information

• Product Name: methyl 4-(aminocarbonyl)-2-nitrobenzoate
• Synonyms: methyl 4-(aminocarbonyl)-2-nitrobenzoate;Methyl-4-(aminocarbonyl)-2-nitrobenzoat;4-Carbamoyl-2-nitrobenzoic acid methyl ester;Einecs 243-537-8
• CAS NO: 20132-75-6
• Molecular Formula: C₉H₈N₂O₅
• Molecular Weight: 224.17022
• EINECS: 243-537-8
• Mol File: 20132-75-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 351.3°C at 760 mmHg
• Flash Point: 166.3°C
• Appearance: /
• Density: 1.419g/cm³
• Vapor Pressure: 4.13E-05mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: methyl 4-(aminocarbonyl)-2-nitrobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(aminocarbonyl)-2-nitrobenzoate(20132-75-6)
• EPA Substance Registry System: methyl 4-(aminocarbonyl)-2-nitrobenzoate(20132-75-6)

Safety Data

• Hazardous Substances Data: 20132-75-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H8N2O5/c1-16-9(13)6-3-2-5(8(10)12)4-7(6)11(14)15/h2-4H,1H3,(H2,10,12)

Upstream product

• 55737-62-7 methyl 4-(chlorocarbonyl)-2-nitrobenzoate 
• 120-61-6 1,4-benzenedicarboxylic acid dimethyl ester 
• 5292-45-5 dimethyl 2-nitroterephthalate 
• 35092-89-8 4-(methoxycarbonyl)-3-nitrobenzoic acid 

Downstream Products

• 652998-62-4 Methyl 4-(aminocarbonyl)-2-(ethylamino)benzoate 
• 52449-76-0 2-nitro-4-cyanobenzoic acid methyl ester 

Relevant articles and documents

Method for preparing 2-amino-4-aminomethyl methyl benzoate and hydrochloride thereof

The invention relates to the field of organic synthesis, and discloses a method for preparing 2-amino-4-aminomethyl methyl benzoate and hydrochloride thereof. The method comprises the following steps:1) sequentially contacting dimethyl terephthalate with a nitration reagent and acetic acid to obtain 3-nitro-4-methoxycarbonyl benzoic acid; (2) converting the 3-nitro-4-methoxycarbonyl benzoic acidinto 2-nitro-4-methoxycarbonyl benzoyl chloride, and enabling the 2-nitro-4-methoxycarbonyl benzoyl chloride to be in contact with ammonia gas so as to obtain methyl 2-nitro-4-formylaminobenzoate; 3)performing dehydration reaction on the 2-nitro-4-formylaminobenzoic acid methyl ester to obtain 2-nitro-4-cyanobenzoic acid methyl ester, and 4) performing reduction reaction on the 2-nitro-4-cyanobenzoic acid methyl ester to obtain 2-amino-4-aminomethyl benzoate. The preparation method has the advantages of high yield, high purity and environmental protection.

FUROISOQUINOLINE DERIVATIVE AND USE THEREOF

The present invention provides a compound represented by the formula ???wherein A represents (1) a bond, (2) a group represented by the formula -CRa=CRb- (Ra and Rb each represent a hydrogen atom or C1-6 alkyl) and the like; R1 represents (1) cyano or (2) an optionally esterified or amidated carboxyl group; R2 represents(1) a hydrogen atom, (2) an optionally substituted hydroxy group,(3) an optionally substituted amino group and the like; R3 and R4 each represent a hydrogen atom and the like; R5 represents a hydrogen atom and the like; R6 represents an optionally substituted hydroxy group and the like; R7and R8 each represent an optionally substituted hydrocarbon group and the like; R9 and R10 each represent (1) a hydrogen atom and the like; Y represents an optionally substituted methylene group; and n represents 0 or 1, or a salt thereof, which has an excellent phosphodiesterase IV inhibiting action.