201478-72-0

Basic information

• Product Name: 3-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
• Synonyms: N-CBZ-3-FORMYLPIPERIDINE;N-CBZ-3-PIPERIDINYLCARBOXALDEHYDE;BENZYL 3-FORMYLPIPERIDINE-1-CARBOXYLATE;1-CBZ-PIPERIDINE-3-ALDEHYDE;3-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;Benzyl 3-formylpiperidine-1-carboxylate 97%;1-Cbz-3-Piperidinecarboxaldehyde;N-CBZ-3-piperidinecarboxaldehyde
• CAS NO: 201478-72-0
• Molecular Formula: C₁₄H₁₇NO₃
• Molecular Weight: 247.29
• Mol File: 201478-72-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 384.503 °C at 760 mmHg
• Flash Point: 186.341 °C
• Appearance: /
• Density: 1.222 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.594
• PKA: -2.34±0.40(Predicted)
• CAS DataBase Reference: 3-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER(201478-72-0)
• EPA Substance Registry System: 3-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER(201478-72-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 201478-72-0(Hazardous Substances Data)

Usage

General Description

3-Formyl-piperidine-1-carboxylic Acid Benzyl Ester is a chemical compound that belongs to the class of organic compounds known as aryl-aliphatic ketones. It is predominantly used in the field of organic chemistry as an intermediate due to its reactive carbonyl group. The molecular structure of this compound includes a piperidine ring, which is a six-membered ring with one nitrogen atom, a benzyl ester group, and a formyl group. The chemical formula for this compound is C16H19NO3. Although its properties like toxicity and biological activity are not widely studied or reported, its reactions and transformations are significant in the synthesis of more complex chemicals within the pharmaceutical and chemical industries.

InChI:InChI=1/C14H17NO3/c16-10-13-7-4-8-15(9-13)14(17)18-11-12-5-2-1-3-6-12/h1-3,5-6,10,13H,4,7-9,11H2

Upstream product

• 39945-51-2 benzyl 3-(hydroxymethyl)-1-piperidinecarboxylate 
• 4606-65-9 3-(hydroxymethy)piperidine 
• 42116-21-2 2-benzyloxycarbonylsulfanyl-4,6-dimethyl-pyrimidine 
• 87413-09-0 Dess-Martin periodane 
• 405239-72-7 benzyl 3-[methoxy(methyl)carbamoyl]piperidine-1-carboxylate 
• 501-53-1 benzyl chloroformate 
• 310454-53-6 3-ethyl 1-(phenylmethyl) 1,3-piperidinedicarboxylate 
• 71962-74-8 Ethyl nipecotate 

Downstream Products

• 712353-22-5 C₂₆H₂₈N₂O₄S 
• 405239-74-9 tert-butyl 2-amino-4-{1-[(benzyloxy)carbonyl]-3-piperidinyl}-6-{2-[(4-methoxybenzyl)oxy]phenyl}nicotinate 
• 1245212-11-6 3,3-(2,3-dihydro-1H-indol-3-yl)-piperidine-1-carboxylic acid benzyl ester 
• 876148-23-1 1-benzyloxycarbonyl-3-[2-[2-(4-chlorophenyl)-4-methylthiazol-5-yl]ethenyl]piperidine 
• 1341126-88-2 benzyl 3-{[(2-aminoethyl)amino]methyl}piperidine-1-carboxylate 
• 1341126-87-1 benzyl 3-[(1,1-dioxido-1,2,5-thiadiazolidin-2-yl)methyl]piperidine-1-carboxylate 
• 1341126-85-9 1-benzyl-3-[(1,1-dioxido-1,2,5-thiadiazolidin-2-yl)methyl]piperidine 
• 784080-46-2 3-(1H-imidazol-5-yl)piperidine 
• 1352654-77-3 benzyl 3-(1H-imidazol-2-yl)piperidine-1-carboxylate 
• 1352654-87-5 benzyl 3-(1H-imidazol-5-yl)piperidine-1-carboxylate 

Relevant articles and documents

Potent inhibition of Norwalk virus by cyclic sulfamide derivatives

A new class of compounds that exhibit anti-norovirus activity in a cell-based system and embody in their structure a cyclosulfamide scaffold has been identified. The structure of the initial hit (compound 2a, ED50 4 μM, TD50 50 μM) has been prospected by exploiting multiple points of diversity and generating appropriate structure-activity relationships.

Disubstituted pyrimidines as Lck inhibitors

We have developed a family of 4-benzimidazolyl-N-piperazinethyl-pyrimidin-2-amines that are subnanomolar inhibitors of Lck. A subset of these Lck inhibitors, with heterocyclic substituents at the benzimidazole C5, are also low-nanomolar inhibitors of cell

Pyridine derivatives

Pyridine compounds of general formula: wherein —R1represents in which R11is hydrogen, C1-6alkyl, halogen, hydroxy, C1-12alkoxy, nitro, amino, C1-6alkylsulfonylamino, C1-6alkoxycarbonyl, C1-6alkylamino, di(C1-6alkyl)amino, C1-6alkanoylamino, phenyl C1-6alkylamino, phenylsulfonylamino, or —O—(CH2)n—R111; R2represents hydrogen or halogen; R3represents hydrogen, —CR31R32R33, or —NR34R35; R4is hydrogen, carbamoyl, CN, carboxyl, etc.; R5is amino, C1-6alkylamino, di C1-6alkylamino, etc. or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.