201940-08-1 Usage
Description
tert-Butyl 5-bromoisoindoline-2-carboxylate is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical agents. It is characterized by its unique molecular structure, which includes a tert-butyl group, a bromo substituent, and an isoindoline-2-carboxylate moiety. tert-Butyl 5-bromoisoindoline-2-carboxylate plays a crucial role in the development of new drugs with improved therapeutic properties.
Uses
Used in Pharmaceutical Industry:
tert-Butyl 5-bromoisoindoline-2-carboxylate is used as a synthetic intermediate for the preparation of Isothiazoloquinolones, which exhibit enhanced antistaphylococcal activities against multidrug-resistant strains of Staphylococcus aureus. These Isothiazoloquinolones have the potential to combat antibiotic-resistant bacterial infections, addressing a significant global health concern.
Additionally, tert-Butyl 5-bromoisoindoline-2-carboxylate is used as a precursor in the synthesis of substituted isoindolines, which act as inhibitors of dipeptidyl peptidase 8/9 (DPP8/9). DPP8/9 inhibitors are of interest in the development of treatments for various diseases, including type 2 diabetes and neurodegenerative disorders, due to their role in regulating peptide processing and inflammation.
Check Digit Verification of cas no
The CAS Registry Mumber 201940-08-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,1,9,4 and 0 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 201940-08:
(8*2)+(7*0)+(6*1)+(5*9)+(4*4)+(3*0)+(2*0)+(1*8)=91
91 % 10 = 1
So 201940-08-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H16BrNO2/c1-13(2,3)17-12(16)15-7-9-4-5-11(14)6-10(9)8-15/h4-6H,7-8H2,1-3H3
201940-08-1Relevant articles and documents
APPLICATION OF MONOCYCLIC BETA-LACTAM COMPOUND IN PHARMACY
-
, (2021/11/04)
An application of a compound represented by formula (I) and pharmaceutically acceptable salts thereof in preparation of a drug for treating pneumonia.
2-Amino-2,3-dihydro-1 H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy
Zhu, Dongsheng,Huang, Huocong,Pinkas, Daniel M.,Luo, Jinfeng,Ganguly, Debolina,Fox, Alice E.,Arner, Emily,Xiang, Qiuping,Tu, Zheng-Chao,Bullock, Alex N.,Brekken, Rolf A.,Ding, Ke,Lu, Xiaoyun
, p. 7431 - 7444 (2019/08/20)
A series of 2-amino-2,3-dihydro-1H-indene-5-carboxamides were designed and synthesized as new selective discoidin domain receptor 1 (DDR1) inhibitors. One of the representative compounds, 7f, bound with DDR1 with a Kd value of 5.9 nM and suppre
THIAZOLE DERIVATIVE AND APPLICATIONS THEREOF
-
, (2020/01/02)
Disclosed in the present invention are a new thiazole compound, particularly a compound represented by formula (I), a pharmaceutical composition thereof and applications thereof in the preparation of drugs for the treatment of diseases related to herpes simplex viruses.