202069-85-0

Basic information

• Product Name: 4-p-tolyl-pyridin-3-ol
• Synonyms: 4-p-tolyl-pyridin-3-ol
• CAS NO: 202069-85-0
• Molecular Weight: 185.225
• Mol File: 202069-85-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-p-tolyl-pyridin-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-p-tolyl-pyridin-3-ol(202069-85-0)
• EPA Substance Registry System: 4-p-tolyl-pyridin-3-ol(202069-85-0)

Safety Data

• Hazardous Substances Data: 202069-85-0(Hazardous Substances Data)

Upstream product

• 5720-05-8 4-methylphenylboronic acid 
• 10128-71-9 3-hydroxyisonicotinic acid 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 76509-17-6 3-benzyloxypyridine 

Relevant articles and documents

A tautomeric ligand enables directed C-H hydroxylation with molecular oxygen

Hydroxylation of aryl carbon-hydrogen bonds with transition metal catalysts has proven challenging when oxygen is used as the oxidant. Here, we report a palladium complex bearing a bidentate pyridine/ pyridone ligand that efficiently catalyzes this reaction at ring positions adjacent to carboxylic acids. Infrared, x-ray, and computational analysis support a possible role of ligand tautomerization from monoanionic (L,X) to neutral (L,L) coordination in the catalytic cycle of aerobic carbon-hydrogen hydroxylation reaction. The conventional site selectivity dictated by heterocycles is overturned by this catalyst, thus allowing late-stage modification of compounds of pharmaceutical interest at previously inaccessible sites.