202133-30-0

Basic information

• Product Name: 1-(2-fluoro-4-nitrophenyl)-4-(pyridin-2-yl)piperazine
• Synonyms: 1-(2-fluoro-4-nitrophenyl)-4-(pyridin-2-yl)piperazine
• CAS NO: 202133-30-0
• Molecular Weight: 302.308
• Mol File: 202133-30-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(2-fluoro-4-nitrophenyl)-4-(pyridin-2-yl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-fluoro-4-nitrophenyl)-4-(pyridin-2-yl)piperazine(202133-30-0)
• EPA Substance Registry System: 1-(2-fluoro-4-nitrophenyl)-4-(pyridin-2-yl)piperazine(202133-30-0)

Safety Data

• Hazardous Substances Data: 202133-30-0(Hazardous Substances Data)

Upstream product

• 34803-66-2 1-(2-pyridyl)piperazine 
• 369-34-6 3,4-difluoronitrobenzene 

Downstream Products

• 1580002-64-7 (E)-N-{3-fluoro-4-[4-(pyridin-2-yl)piperazin-1-yl]phenyl}cinnamamide 
• 1580002-72-7 (E)-N-{3-fluoro-4-[4-(pyridin-2-yl)piperazin-1-yl]phenyl}-3-(4-nitrophenyl)acrylamide 
• 202133-37-7 Methanesulfonic acid (R)-3-[3-fluoro-4-(4-pyridin-2-yl-piperazin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl ester 
• 202132-88-5 N-{(S)-3-[3-Fluoro-4-(4-pyridin-2-yl-piperazin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 
• 202133-33-3 N-benzyloxycarbonyl-3-fluoro-4-[4-(2-pyridyl)piperazin-1-yl]aniline 
• 735276-51-4 (S)-5-Aminomethyl-3-[3-fluoro-4-(4-pyridin-2-yl-piperazin-1-yl)-phenyl]-oxazolidin-2-one 
• 202133-35-5 (R)-(3-{3-fluoro-4-[4-(2-pyridyl)piperazin-1-yl]phenyl}-2-oxo-5-oxazolidinyl)methanol 
• 202133-31-1 3-fluoro-4-[4-(pyridin-2-yl)piperazin-1-yl]aniline 

Relevant articles and documents

Piperazinyl oxazolidinone antibacterial agents containing a pyridine, diazene, or triazene heteroaromatic ring

Oxazolidinones are a novel class of synthetic antibacterial agents active against gram-positive organisms including methicillin-resistant Staphylococcus aureus as well as selected anaerobic organisms. Important representatives of this class include the mo

Benzofuroxan Derivatives as Potent Agents against Multidrug-Resistant Mycobacterium tuberculosis

Tuberculosis (TB) is currently the leading cause of death related to infectious diseases worldwide, as reported by the World Health Organization. Moreover, the increasing number of multidrug-resistant tuberculosis (MDR-TB) cases has alarmed health agencies, warranting extensive efforts to discover novel drugs that are effective and also safe. In this study, 23 new compounds were synthesized and evaluated in vitro against the drug-resistant strains of M. tuberculosis. The compound 6-((3-fluoro-4-thiomorpholinophenyl)carbamoyl)benzo[c][1,2,5]oxadiazole 1-N-oxide (5 b) was particularly remarkable in this regard as it demonstrated MIC90 values below 0.28 μM against all the MDR strains evaluated, thus suggesting that this compound might have a different mechanism of action. Benzofuroxans are an attractive new class of anti-TB agents, exemplified by compound 5 b, with excellent potency against the replicating and drug-resistant strains of M. tuberculosis.

PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE

The present invention relates to compounds of general formula (I): wherein A, Y, X, n and B are as defined herein; and their use in the treatment and prevention of metabolic disorders, inflammatory conditions, allergic conditions, fever, pain including allodynia and nociception, eating disorders, cachexia, brain injuries, cancer of the genitals, sleep apnoea, cardiovascular disease, flush effect associated with nicotinic acid and related compounds or for the promotion of wound healing. Certain compounds of general formula (I) are new and the invention also relates to these compounds and to their use in medicine.