202466-76-0

Basic information

• Product Name: 4-amino-N-(2-bromo-6-methylaminopyridin-4-yl)benzenesulfonamide
• Synonyms: 4-amino-N-(2-bromo-6-methylaminopyridin-4-yl)benzenesulfonamide
• CAS NO: 202466-76-0
• Molecular Weight: 357.231
• Mol File: 202466-76-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-amino-N-(2-bromo-6-methylaminopyridin-4-yl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-N-(2-bromo-6-methylaminopyridin-4-yl)benzenesulfonamide(202466-76-0)
• EPA Substance Registry System: 4-amino-N-(2-bromo-6-methylaminopyridin-4-yl)benzenesulfonamide(202466-76-0)

Safety Data

• Hazardous Substances Data: 202466-76-0(Hazardous Substances Data)

Upstream product

• 202467-46-7 N-[4-(2,6-dibromopyridin-4-ylsulfamoyl)phenyl]acetamide 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 39771-34-1 4-amino-2,6-dibromopyridine 
• 74-89-5 methylamine 
• 202467-14-9 4-amino-N-(2,6-dibromopyridin-4-yl)benzenesulfonamide 

Downstream Products

• 202467-19-4 4-Amino-N-(2-methylamino-pyridin-4-yl)-benzene-sulfonamide 

Relevant articles and documents

5-HT6 receptor antagonists: lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides

RO-04-6790 (6a) has been identified in a random screen for 5-HT6 receptor antagonists. In a medicinal chemistry optimisation program a series of analogs comprising N-heteroaryl- and N-arylbenzenesulfonamides have been synthesised and investigated for their binding affinity. Compounds with a log D profile indicative of brain penetration have been subjected to in vivo testing for reversal of a scopolamine-induced retention deficit in a passive avoidance paradigm.