20254-76-6

Basic information

• Product Name: 3-CHLOROQUINOXALINE-2-CARBOXYLIC ACID
• Synonyms: 3-CHLOROQUINOXALINE-2-CARBOXYLIC ACID;3-chloroquinoxaline-2-carboxylic acid(SALTDATA: FREE);2-Quinoxalinecarboxylic acid, 3-chloro-
• CAS NO: 20254-76-6
• Molecular Formula: C₉H₅ClN₂O₂
• Molecular Weight: 208.61
• Mol File: 20254-76-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /Solid
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-CHLOROQUINOXALINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLOROQUINOXALINE-2-CARBOXYLIC ACID(20254-76-6)
• EPA Substance Registry System: 3-CHLOROQUINOXALINE-2-CARBOXYLIC ACID(20254-76-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 20254-76-6(Hazardous Substances Data)

Usage

General Description

3-Chloroquinoxaline-2-carboxylic acid is a chemical compound with the molecular formula C9H5ClN2O2. It is a chlorinated derivative of quinoxaline-2-carboxylic acid and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 3-CHLOROQUINOXALINE-2-CARBOXYLIC ACID has been found to possess antimicrobial and antiproliferative properties, making it a potential candidate for the development of new drugs. Its properties and applications make 3-Chloroquinoxaline-2-carboxylic acid a valuable compound in the field of medicinal chemistry and chemical synthesis.

Upstream product

• 49679-45-0 ethyl 3-chloroquinoxaline-2-carboxylate 
• 32601-86-8 2-chloro-3-methylquinoxaline 
• 7065-23-8 ethyl quinoxaline-2-carboxylate 
• 23395-75-7 ethyl 2-quinoxalinecarboxylate 4-oxide 
• 36818-07-2 ethyl 3-oxo-4H-quinoxaline-2-carboxylate 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 1448-87-9 2-chloroquinoxaline 
• 49679-41-6 3-chloroquinoxaline-2-carbonyl chloride 
• 57315-47-6 2-ethoxyquinoxaline 
• 1276684-93-5 C₂₂H₂₄N₄O₃ 
• 1276684-95-7 C₂₁H₂₁ClN₄O₂ 
• 1223954-52-6 (4-(3-chlorophenyl)piperazin-1-yl)(3-ethoxyquinoxalin-2-yl)methanone 
• 1276684-97-9 C₂₂H₂₁F₃N₄O₂ 
• 1276684-98-0 C₂₂H₂₄N₄O₂ 
• 1276685-08-5 C₂₁H₂₄N₄O₂ 
• 1276684-91-3 C₂₁H₂₂N₄O₂ 

Relevant articles and documents

Pharmacophore based synthesis of 3-chloroquinoxaline-2-carboxamides as serotonin3 (5-HT3) receptor antagonist

A series of 3-chloroquinoxaline-2-carboxamides were designed and prepared by the condensation of 3-chloro-2-quinoxaloylchloride with appropriate Mannich bases of the p-aminophenol in the microwave environment. The synthesized compounds were evaluated for serotonin3 (5-HT3) receptor antagonistic activities in longitudinal muscle-myenteric plexus (LMMP) preparation from guinea pig ileum against the 5-HT3 agonist, 2-methyl-5-HT. Compound 3g exhibited comparable 5-HT3 antagonistic activity (pA2 6.4) to that of standard antagonist Ondansetron (pA2 6.9), while the other compounds exhibited mild to moderate 5-HT3 antagonistic activities.

Discovery of new anti-depressants from structurally novel 5-HT3 receptor antagonists: Design, synthesis and pharmacological evaluation of 3-ethoxyquinoxalin-2-carboxamides

A novel series of 3-ethoxyquinoxalin-2-carboxamides were designed as per the pharmacophoric requirements of 5-HT3 receptor antagonist using ligand-based approach. The desired carboxamides were synthesized from the key intermediate, 3-ethoxyquin