203788-46-9

Basic information

• Product Name: 2-(1-Phenyl-ethyl)-2,3-dihydro-isoindol-1-one
• Synonyms: 2-(1-Phenyl-ethyl)-2,3-dihydro-isoindol-1-one
• CAS NO: 203788-46-9
• Molecular Weight: 237.301
• Mol File: 203788-46-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(1-Phenyl-ethyl)-2,3-dihydro-isoindol-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-Phenyl-ethyl)-2,3-dihydro-isoindol-1-one(203788-46-9)
• EPA Substance Registry System: 2-(1-Phenyl-ethyl)-2,3-dihydro-isoindol-1-one(203788-46-9)

Safety Data

• Hazardous Substances Data: 203788-46-9(Hazardous Substances Data)

Usage

Physical state

White solid

Molecular weight

239.31 g/mol

Common uses

Fragrance industry as a scenting agent, production of perfumes, soaps, and other personal care products

Odor

Floral, powdery, and musky

Potential applications

Synthesis of various drugs and pharmaceutical compounds

Upstream product

• 618-36-0 rac-methylbenzylamine 
• 643-79-8 o-phthalic dicarboxaldehyde 

Downstream Products

• 3976-26-9 2-(1-phenylethyl)isoindoline-1,3-dione 

Relevant articles and documents

Recent progress of phthalimidine syntheses

Phthalimidine (2,3-dihydro-1H-isoindol-1-one) syntheses in recent years are reviewed primarily for those involving synthetic auxiliary-mediated mild Mannich type condensation reactions.

A facile scheme for phthalimide ? phthalimidine conversion

Desulfurization of phenylthiolactams using an ultrasound-promoted Raney nickel protocol yields the corresponding N-substituted phthalimidines. Benzylic oxidation of the N-substituted phthalimidines by treatment with 2,2'-bipyridinium chlorochromate/m-chloroperbenzoic acid (BPCC/MCPBA) affords the original phthalimides. The reduction-desulfurization is applied to the preparation of a deoxythalidomide derivative which is a TNF-α inhibitor.