204078-48-8

Basic information

• Product Name: 2-MORPHOLINOBENZYLAMINE
• Synonyms: ART-CHEM-BB B021974;BUTTPARK 98\16-71;2-MORPHOLINOBENZYLAMINE;AKOS B021974;RARECHEM AL BW 1931;2-(4-Morpholino)benzylamine;2-(4-Morpholino)benzylamine 97%;2-(4-Morpholino)benzylamine97%
• CAS NO: 204078-48-8
• Molecular Formula: C₁₁H₁₆N₂O
• Molecular Weight: 192.26
• Product Categories: Aminomethyl's;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 204078-48-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 346.7°C at 760 mmHg
• Flash Point: 163.5°C
• Appearance: /
• Density: 1.113g/cm³
• Vapor Pressure: 5.65E-05mmHg at 25°C
• Refractive Index: 1.568
• PKA: 9.90±0.10(Predicted)
• CAS DataBase Reference: 2-MORPHOLINOBENZYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-MORPHOLINOBENZYLAMINE(204078-48-8)
• EPA Substance Registry System: 2-MORPHOLINOBENZYLAMINE(204078-48-8)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 2735
• HazardClass: IRRITANT
• Hazardous Substances Data: 204078-48-8(Hazardous Substances Data)

Usage

General Description

2-Morpholinobenzylamine is a chemical compound with the molecular formula C11H16N2O. It is a primary amine with a morpholine group attached to a benzene ring. 2-MORPHOLINOBENZYLAMINE is commonly used as a building block in the synthesis of various pharmaceuticals and fine chemicals. It is also known for its potential use as an anti-inflammatory and anti-cancer agent. 2-Morpholinobenzylamine is a white to off-white solid with a melting point of around 83-86°C and is typically stored in a cool and dry place away from light and moisture. It is important to handle this chemical with proper safety precautions as it can be irritating to the eyes, skin, and respiratory system.

InChI:InChI=1/C11H16N2O/c12-9-10-3-1-2-4-11(10)13-5-7-14-8-6-13/h1-4H,5-9,12H2

Upstream product

• 110-91-8 morpholine 
• 394-47-8 2-fluorobenzonitrile 
• 204078-32-0 2-(4-morpholino)benzonitrile 

Downstream Products

• 1258268-90-4 C₂₃H₂₂ClN₃O₂ 
• 1313212-61-1 ethyl 2-(3-(2-morpholinobenzyl)ureido)acetate 

Relevant articles and documents

Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H- tetrazol-5-amine P2X7 antagonists

Synthesis and biological evaluation of a novel class of substituted N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine derivatives resulted in the identification of potent P2X7 antagonists. These compounds were assayed for activity at both the

Aminoborohydrides. 12. Novel tandem SNAr amination-reduction reactions of 2-halobenzonitriles with lithium N,N-dialkylaminoborohydrides

A novel tandem amination-reduction reaction has been developed in which 2-(N,N-dialkylamino)benzylamines are generated from 2-halobenzonitriles and lithium N,N-dialkylaminoborohydride (LAB) reagents. These reactions are believed to occur through a tandem SNAr amination-reduction mechanism wherein the LAB reagent promotes halide displacement by the N,N-dialkylamino group, and the nitrile is subsequently reduced. This one-pot procedure is complimentary to existing synthetic methods and is an attractive synthetic tool for the nucleophilic aromatic substitution of halobenzenes with less nucleophilic amines. The (N,N-dialkylamino)benzylamine products of this reaction are easily isolated after a simple aqueous workup procedure in very good to excellent yields.