20426-80-6

Basic information

• Product Name: 4-Chromancarboxylic acid
• Synonyms: 4-Chromancarboxylic acid;2H-1-Benzopyran-4-carboxylic acid, 3,4-dihydro-;chroman-4-carboxylic acid;3,4-dihydro-2H-1-Benzopyran-4-carboxylic acid
• CAS NO: 20426-80-6
• Molecular Formula: C₁₀H₁₀O₃
• Molecular Weight: 178
• Mol File: 20426-80-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 90.0-91.5 °C
• Boiling Point: 334.4±41.0 °C(Predicted)
• Appearance: /
• Density: 1.276±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.97±0.20(Predicted)
• CAS DataBase Reference: 4-Chromancarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chromancarboxylic acid(20426-80-6)
• EPA Substance Registry System: 4-Chromancarboxylic acid(20426-80-6)

Safety Data

• Hazardous Substances Data: 20426-80-6(Hazardous Substances Data)

Usage

General Description

4-Chromancarboxylic acid, also known as 4-hydroxy-1H-chromene-2-carboxylic acid, is a chemical compound with the molecular formula C9H6O4. It is a carboxylic acid derivative of chroman that has a hydroxy group at position 4 on the chromene ring. 4-Chromancarboxylic acid is commonly used in organic synthesis and pharmaceutical research due to its potential biological activities. It has been studied for its antioxidant and anti-inflammatory properties, as well as its potential therapeutic effects on cancer and neurodegenerative diseases. 4-Chromancarboxylic acid also shows promising industrial applications in the manufacture of various pharmaceuticals and chemicals.

Upstream product

• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 7677-24-9 trimethylsilyl cyanide 
• 113967-29-6 methyl chroman-4-carboxylate 
• 74187-63-6 4-((trimethylsilyl)oxy)chroman-4-carbonitrile 
• 6786-30-7 3,4-dihydro-1-benzoxepin-5(2H)-one 
• 20426-78-2 4-bromo-3,4-dihydro-1(2H)-benzoxepin-5-one 
• 113967-32-1 4-Bromo-5,5-dimethoxy-2,3,4,5-tetrahydro-benzo[b]oxepine 
• 493-08-3 chromane 
• 124-38-9 carbon dioxide 

Downstream Products

• 1401466-95-2 diethyl (R)-4-((R)-1-phenylallyl)chroman-4-carbonylphosphonate 
• 1343394-83-1 (rac)-chromane-4-carboxylic acid chloride 
• 1392493-59-2 N-(2-(pyrrolidin-1-yl)phenyl)chroman-4-carboxamide 

Relevant articles and documents

BCL-2 INHIBITOR

Disclosed herein is a compound of Formula (I) for inhibiting both Bcl-2 wild type and mutated Bcl-2, in particular, Bcl-2 G101V and D103Y, and a method of using the compound disclosed herein for treating dysregulated apoptotic diseases.

DUAL NAV1.2/5HT2A INHIBITORS FOR TREATING CNS DISORDERS

Compounds of formula I: I are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disorders in a patient in need are also disclosed. Such disorders include depression, bipolar disorder, pain, schizophrenia, obsessive compulsive disorder, addiction, social disorder, attention deficit hyperactivity disorder, an anxiety disorder, autism, a cognitive impairment, or a neuropsychiatric symptom such as apathy, depression, anxiety, psychosis, aggression, agitation, impulse control disorders, and sleep disorders in neurological disorders such as Alzheimer's and Parkinson's diseases.

HISTONE DEMETHYLASE INHIBITORS

This disclosure relates to compounds that inhibit histone demethylase activity. In particular, the disclosure relates to compounds that inhibit histone lysine demethylase KDM5B, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions disclosed herein.