2043-10-9 Usage
Description
(dichloromethyl)(dimethyl)silyl, also known as trimethylsilyldichloromethane, is a silylating agent characterized by a silicon atom bonded to three methyl groups and two chlorine atoms. It is highly reactive towards nucleophilic substitution reactions and is widely utilized in organic synthesis. (dichloromethyl)(dimethyl)silyl is also recognized for its role as a protective group for alcohols and amines, making it a versatile reagent in the field of synthetic chemistry.
Uses
Used in Organic Synthesis:
(dichloromethyl)(dimethyl)silyl is used as a silylating agent for facilitating various organic reactions. Its reactivity towards nucleophilic substitution reactions allows for the formation of a range of organosilicon compounds, which are essential in the development of new molecules and materials.
Used in Protective Group Chemistry:
In the pharmaceutical and chemical industries, (dichloromethyl)(dimethyl)silyl serves as a protective group for alcohols and amines. This application is crucial for preventing unwanted side reactions during the synthesis of complex molecules, ensuring the selective protection of functional groups until they are needed for further reactions.
Used in Biomolecule Modification:
(dichloromethyl)(dimethyl)silyl is also employed in the modification of biomolecules for research and industrial applications. Its ability to react with nucleophilic sites on biomolecules allows for the creation of novel bioactive compounds and the study of their interactions with biological systems.
Overall, (dichloromethyl)(dimethyl)silyl is a valuable reagent in the field of synthetic chemistry, with applications spanning across organic synthesis, protective group chemistry, and biomolecule modification. Its versatility and reactivity make it an essential tool for researchers and chemists working with a wide range of chemical and biological systems.
Check Digit Verification of cas no
The CAS Registry Mumber 2043-10-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,0,4 and 3 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2043-10:
(6*2)+(5*0)+(4*4)+(3*3)+(2*1)+(1*0)=39
39 % 10 = 9
So 2043-10-9 is a valid CAS Registry Number.
2043-10-9Relevant articles and documents
Simplified preparations of trialkylsilyl- and bis(trialkylsilyl)dihalomethanes via the deprotonation of dihalomethanes
Yoon, Kunsang,Son, David Y.
, p. 185 - 189 (1997)
Simple, high-yield routes to trialkylsilyl- and bis(trialkylsilyl)dihalomethanes are described. These compounds are prepared by the deprotonation of dibromomethane or dichloromethane by lithium diisopropylamide in the presence of a chlorosilane. The reactions are carried out at temperatures below - 70°C in THF/hexane solvent mixtures. After aqueous workup, the air- and water-stable products are isolated by either distillation or crystallization. Further reactions on these compounds are possible, as illustrated by one example.
