204692-44-4Relevant articles and documents
Structure-Based Drug Discovery of N-((R)-3-(7-Methyl-1 H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3- d][1,3]oxazine]-1-carboxam
Bucknell, Sarah J.,Ator, Mark A.,Brown, Alastair J. H.,Brown, Jason,Cansfield, Andrew D.,Cansfield, Julie E.,Christopher, John A.,Congreve, Miles,Cseke, Gabriella,Deflorian, Francesca,Jones, Christopher R.,Mason, Jonathan S.,O'Brien, M. Alistair,Ott, Gregory R.,Pickworth, Mark,Southall, Stacey M.
, p. 7906 - 7920 (2020)
Structure-based drug design enabled the discovery of 8, HTL22562, a calcitonin gene-related peptide (CGRP) receptor antagonist. The structure of 8 complexed with the CGRP receptor was determined at a 1.6 ? resolution. Compound 8 is a highly potent, select
Modified aminoacids, pharmaceuticals containing these compounds and method for their production
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Example A24, (2008/06/13)
The present invention relates to modified amino acids of general formula wherein A, Z, X, n, m, R, R2, R3, R4and R11are defined as in claims 1 to 5, their tautomers, their diastereomers, their enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them as well as their use for the production and purification of antibodies and as labelled compounds in RIA- and ELISA assays and as diagnostic or analytical aids in neurotransmitter research.