20488-10-2

Basic information

• Product Name: Benzene, 1-bromo-4-(1-chloroethyl)-
• CAS NO: 20488-10-2
• Molecular Formula: C8H8BrCl
• Molecular Weight: 219.509
• Mol File: 20488-10-2.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzene, 1-bromo-4-(1-chloroethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-bromo-4-(1-chloroethyl)-(20488-10-2)
• EPA Substance Registry System: Benzene, 1-bromo-4-(1-chloroethyl)-(20488-10-2)

Safety Data

• Hazardous Substances Data: 20488-10-2(Hazardous Substances Data)

Upstream product

• 1585-07-5 1-bromo-4-ethylbenzene 
• 99-90-1 para-bromoacetophenone 
• 5391-88-8 1-(4-bromophenyl)ethanol 

Downstream Products

• 54758-83-7 C₂₀H₁₇BrO₂ 
• 5391-88-8 1-(4-bromophenyl)ethanol 
• 119999-16-5 2-<3-(4-Bromophenyl)buten-2-yl>-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene 
• 119999-15-4 2-(4-Bromo-phenyl)-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propan-1-one 
• 119999-14-3 2-[1-(4-Bromo-phenyl)-ethyl]-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-[1,3]dithiane 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 138622-99-8 tert-butyl 2-(4-bromophenyl)propionate 
• 16483-42-4 meso-2.3-bis-(4-bromo-phenyl)-butane 
• 1433777-39-9 (R)-4-(4-bromophenyl)-1-(4-methoxyphenyl)pentan-3-one 
• 1226985-81-4 C₁₄H₂₁BrN₂ 
• 1073716-76-3 C₂₈H₂₇BrN₄O 
• 933785-13-8 1-[1-(4-bromophenyl)ethyl]azetidine 
• 933785-12-7 4-(1-(4-bromophenyl)ethyl)morpholine 

Relevant articles and documents

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Ferric chloride–catalyzed deoxygenative chlorination of carbonyl compounds: A comparison of chlorodimethylsilane and dichloromethylsilane system

Deoxygenative chlorination of carbonyl compounds using the HMe2SiCl/FeCl3/EtOAc and HMeSiCl2/FeCl3/EtOAc systems has been systemically investigated. The HMe2SiCl-FeCl3 system showed the advantages of good substrate applicability, mild reaction conditions, simple operation, low cost, and easy availability of raw materials. Also, it provided a simple and efficient synthesis route for carbonyl deoxychlorination via a one-pot method. Using the HMeSiCl2/FeCl3/EtOAc system, the β-methylchalcone derivative could be obtained in good yields in addition to obtaining the chlorinated compound. Finally, two plausible reaction routes were proposed to describe the formation of the chlorinated compound and the β-methylchalcone derivative.

Silver-Catalyzed C(sp3)-H Chlorination

A silver-catalyzed chlorination of benzylic, tertiary, and secondary C(sp3)-H bonds was developed. The reaction proceeded with as low as 0.2 mol % catalyst loading at room temperature under air atmosphere with synthetically useful functional group compatibility. The regioselectivity and reactivity tendencies suggest that the chlorination proceeded through a radical pathway, but an intermediate alkylsilver species cannot be ruled out.