205370-10-1

Basic information

• Product Name: 1H-Isoindole,2,3-dihydro-2,5-dimethyl-(9CI)
• Synonyms: 1H-Isoindole,2,3-dihydro-2,5-dimethyl-(9CI)
• CAS NO: 205370-10-1
• Molecular Formula: C10H13N
• Molecular Weight: 147.21692
• Product Categories: AMINETERTIARY
• Mol File: 205370-10-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Isoindole,2,3-dihydro-2,5-dimethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole,2,3-dihydro-2,5-dimethyl-(9CI)(205370-10-1)
• EPA Substance Registry System: 1H-Isoindole,2,3-dihydro-2,5-dimethyl-(9CI)(205370-10-1)

Safety Data

• Hazardous Substances Data: 205370-10-1(Hazardous Substances Data)

Upstream product

• 74-89-5 methylamine 
• 205370-21-4 Methanesulfonic acid 2-methanesulfonyloxymethyl-4-methyl-benzyl ester 
• 4316-23-8 4-methylphthalic acid 
• 90534-49-9 1,2-bishydroxymethyl-4-methylbenzene 
• 29103-90-0 2,5-dimethylisoindoline-1,3-dione 

Relevant articles and documents

Integrated catalytic C-H transformations for one-pot synthesis of 1-arylisoindoles from isoindolines via palladium-catalyzed dehydrogenation followed by C-H arylation

A one-pot conversion of isoindolines to 1-arylisoindoles was established from palladium-catalyzed cascade C-H transformations, that is, the dehydrogenation of isoindolines to give isoindoles, with subsequent C-H arylation of the isoindoles.(Figure Presented)

1-Methyl-3-pyrrolines and 2-methylisoindolines: New classes of cyclic tertiary amine monoamine oxidase B substrates

Both 1-methyl-3-pyrrolines and 2-methylisoindolines are substrates for MAO-B with V(max)/K(m) values ranging from 200 to 2000 min-1 mM-1 at 37°C. These compounds represent new classes of cyclic tertiary amine substrates for this flavoenzyme. The only other known cyclic amines that are MAO-B substrates are 1,4-disubstituted 1,2,3,6-tetrahydropyridinyl derivatives. The presence of an allylic (benzylic) amino functionality in all of these compounds may be linked to their substrate properties since related piperidinyl and pyrrolidinyl analogs are stable in the presence of MAO-B. This paper discusses energetic and geometric features of these compounds in relationship to their substrate properties and in anticipation of their utility to probe the active site of this flavoenzyme.