205756-47-4 Usage
Description
1-(6-Amino-2,3-difluorophenyl)-2,2,2-trifluoroethan-1-one, 3,4-Difluoro-2-(trifluoroacetyl)aniline is a complex organic compound featuring a combination of fluorine-containing functional groups and an aromatic ring. The presence of fluorine atoms in the molecule endows it with unique chemical and physical properties, making it a versatile building block in the synthesis of pharmaceuticals and agrochemicals.
Uses
Used in Pharmaceutical Industry:
1-(6-Amino-2,3-difluorophenyl)-2,2,2-trifluoroethan-1-one, 3,4-Difluoro-2-(trifluoroacetyl)aniline is used as a key intermediate for the synthesis of various drug molecules. 1-(6-Amino-2,3-difluorophenyl)-2,2,2-trifluoroethan-1-one, 3,4-Difluoro-2-(trifluoroacetyl)aniline's fluorinated structure contributes to the development of new pharmaceuticals with improved pharmacokinetic and pharmacodynamic profiles.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(6-Amino-2,3-difluorophenyl)-2,2,2-trifluoroethan-1-one, 3,4-Difluoro-2-(trifluoroacetyl)aniline serves as an intermediate in the production of compounds with pesticidal, herbicidal, or fungicidal properties. The fluorine atoms in the molecule can enhance the bioactivity and selectivity of the final agrochemical products.
Both applications leverage the unique properties of fluorine-containing compounds, which often exhibit increased metabolic stability, lipophilicity, and the ability to modulate the activity of target proteins or enzymes in biological systems.
Check Digit Verification of cas no
The CAS Registry Mumber 205756-47-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,5,7,5 and 6 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 205756-47:
(8*2)+(7*0)+(6*5)+(5*7)+(4*5)+(3*6)+(2*4)+(1*7)=134
134 % 10 = 4
So 205756-47-4 is a valid CAS Registry Number.
205756-47-4Relevant articles and documents
Synthesis and evaluation of analogs of Efavirenz (SUSTIVA(TM)) as HIV-1 reverse transcriptase inhibitors
Patel, Mona,Ko, Soo S.,McHugh Jr., Robert J.,Markwalder, Jay A.,Srivastava, Anurag S.,Cordova, Beverly C.,Klabe, Ronald M.,Erickson-Viitanen, Susan,Trainor, George L.,Seitz, Steven P.
, p. 2805 - 2810 (2007/10/03)
Efavirenz (SUSTIVA(TM)) is a potent non-nucleoside reverse transcriptase inhibitor. Due to the observation of breakthrough mutations of the reverse transcriptase enzyme during Efavirenz therapy, we sought to develop an optimized second generation series. To that end, SAR of the substituents on the aromatic ring was undertaken and the results are summarized here. The 5,6-difluoro (4f) and the 6-methoxy (4m) substituted benzoxazinones were determined to be equipotent, and as a result such substitution patterns will be incorporated in second generation scaffolds.
