205865-67-4 Usage
Description
ETHYL TRIMETHYLSILYLDIFLUOROACETATE, also known as Ethyl 2,2-difluoro-2-(trimethylsilyl)acetate, is a chemical reagent used in organic synthesis. It is characterized by the presence of a difluoromethyl group and a trimethylsilyl group, which contribute to its unique chemical properties and reactivity.
Uses
Used in Organic Synthesis:
ETHYL TRIMETHYLSILYLDIFLUOROACETATE is used as a reagent for difluoromethylation and difluoromethylenation reactions in organic synthesis. Its difluoromethyl group can be selectively introduced into various organic compounds, providing a versatile tool for the synthesis of a wide range of difluoromethylated compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, ETHYL TRIMETHYLSILYLDIFLUOROACETATE is used as a key intermediate in the synthesis of difluoromethyl-containing drugs. The difluoromethyl group is known to impart unique biological properties to the resulting compounds, making them potential candidates for the treatment of various diseases.
Used in Agrochemical Industry:
ETHYL TRIMETHYLSILYLDIFLUOROACETATE is also used in the agrochemical industry for the synthesis of difluoromethyl-containing pesticides and herbicides. The introduction of the difluoromethyl group can enhance the biological activity and selectivity of these agrochemicals, leading to more effective and environmentally friendly products.
Overall, ETHYL TRIMETHYLSILYLDIFLUOROACETATE is a valuable reagent in various fields, including organic synthesis, pharmaceuticals, and agrochemicals, due to its ability to introduce the difluoromethyl group into organic compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 205865-67-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,5,8,6 and 5 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 205865-67:
(8*2)+(7*0)+(6*5)+(5*8)+(4*6)+(3*5)+(2*6)+(1*7)=144
144 % 10 = 4
So 205865-67-4 is a valid CAS Registry Number.
InChI:InChI=1S/C7H14F2O2Si/c1-5-11-6(10)7(8,9)12(2,3)4/h5H2,1-4H3
205865-67-4Relevant articles and documents
Defluorinative silylation toward a selective preparation of α-trimethylsilyl-α,α-difluoroacetates from trifluoroacetates
Uneyama, Kenji,Mizutani, Go
, p. 613 - 614 (1999)
Electrochemical reduction of n-hexyl trifluoroacetate 1a in MeCN, involving Bu4NBr, TMSCl, and Et3N using an H-type divided cell equipped with carbon plate as an anode and lead plate as a cathode at 50°C, provided n-hexyl α-trimethyl
Manufacturing method of making heteroarylacetic compd. defluoromethyl
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Paragraph 0070-0072, (2018/10/03)
PROBLEM TO BE SOLVED: To provide a method for easily producing a difluoromethyl heteroaryl compound with high yield at low cost. SOLUTION: In the method for producing the difluoro methyl heteroaryl compound, a halogenated heteroaryl compound and a α-silyldifluoro acetate ester compound are reacted with each other in the presence of a metal halogenated compound. COPYRIGHT: (C)2012,JPOandINPIT
Nucleophilic fluoroalkylation of (bromomethyl)pinacolborane using silicon reagents
Levin, Vitalij V.,Elkin, Pavel K.,Struchkova, Marina I.,Dilman, Alexander D.
, p. 43 - 46 (2013/11/06)
A method for the synthesis of pinacol boronic esters bearing a fluorinated group at the a-carbon atom (RfCH2Bpin) from corresponding bromomethyl borane (BrCH2Bpin) and fluorinated silanes (RfSiMe3) is described. The fluoroalkylation reaction involves formation of borate anions followed by intramolecular nucleophilic substitution of bromine.