206055-62-1Relevant articles and documents
Design, synthesis, and properties of 2′,4′-BNANC: A bridged nucleic acid analogue
Rahman, S. M. Abdur,Seki, Sayori,Obika, Satoshi,Yoshikawa, Haruhisa,Miyashita, Kazuyuki,Imanishi, Takeshi
, p. 4886 - 4896 (2008/09/21)
The novel bridged nucleic-acid analogue 2′,4′-BNANC (2′-O,4′-C-aminomethylene bridged nucleic acid), containing a six-membered bridged structure with an N-O linkage, was designed and synthesized efficiently, demonstrating a one-pot intramolecul
A new synthetic approach towards α- and β-LNA (locked nucleic acids)
Nielsen, Poul,Wengel, Jesper
, p. 701 - 702 (2007/10/03)
A bicyclo[2.2.1] phenyl thioglycoside was efficiently synthesised and introduced as the key synthon in a novel method for convergent synthesis of β-LNA-nucleosides as well as their α-configurated isomers. An acid-induced ring-opening reaction on the corre
LNA (locked nucleic acids): Synthesis and high-affinity nucleic acid recognition
Singh, Sanjay K.,Nielsen, Poul,Koshkin, Alexei A.,Wengel, Jesper
, p. 455 - 456 (2007/10/03)
A novel class of nucleic acid analogues, termed LNA (locked nucleic acids), is introduced. Following the Watson-Crick base pairing rules, LNA forms duplexes with complementary DNA and RNA with remarkably increased thermal stabilities and generally improve