206055-89-2

Basic information

• Product Name: [3-(4-FLUORO-PHENYL)-ISOXAZOL-5-YL]-METHANOL
• Synonyms: [3-(4-FLUORO-PHENYL)-ISOXAZOL-5-YL]-METHANOL;5-isoxazolemethanol, 3-(4-fluorophenyl)-;Albb-009791;[3-(4-Fluorophenyl)-1,2-oxazol-5-yl]methanol;[3-(4-fluorophenyl)-5-isoxazolyl]methanol;[3-(4-Fluoro-phenyl)-isoxazol-5-yl]-
• CAS NO: 206055-89-2
• Molecular Formula: C₁₀H₈FNO₂
• Molecular Weight: 193.17
• Mol File: 206055-89-2.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 358.46 °C at 760 mmHg
• Flash Point: 170.591 °C
• Appearance: /
• Density: 1.299 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: [3-(4-FLUORO-PHENYL)-ISOXAZOL-5-YL]-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [3-(4-FLUORO-PHENYL)-ISOXAZOL-5-YL]-METHANOL(206055-89-2)
• EPA Substance Registry System: [3-(4-FLUORO-PHENYL)-ISOXAZOL-5-YL]-METHANOL(206055-89-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 206055-89-2(Hazardous Substances Data)

Usage

General Description

[3-(4-Fluoro-phenyl)-isoxazol-5-yl]-methanol is a chemical compound with the molecular formula C10H8FNO2. It is an isoxazole derivative that contains a fluorine-substituted phenyl group. [3-(4-FLUORO-PHENYL)-ISOXAZOL-5-YL]-METHANOL is used in organic synthesis and pharmaceutical research as a building block or intermediate for the production of various drugs and bioactive molecules. Its unique structure and functional groups make it a valuable component for designing and synthesizing new pharmaceutical compounds with potential therapeutic effects. Additionally, [3-(4-Fluoro-phenyl)-isoxazol-5-yl]-methanol may also have potential applications in other fields such as material science and agrochemicals due to its versatile reactivity and properties.

InChI:InChI=1/C10H8FNO2/c11-8-3-1-7(2-4-8)10-5-9(6-13)14-12-10/h1-5,13H,6H2

Upstream product

• 42202-95-9 4-fluoro-N-hydroxybenzimidoyl chloride 
• 107-19-7 propargyl alcohol 
• 459-23-4 (E)-4-fluorobenzaldehyde oxime 
• 753479-66-2 [3-(4-fluorophenyl)isoxazol-5-yl]methyl acetate 
• 459-23-4 4-fluorobenzaldoxime 
• 459-57-4 4-fluorobenzaldehyde 
• 377052-00-1 ethyl 3-(4-fluorophenyl)isoxazole-5-carboxylate 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 31686-94-9 ethyl 4-(4-fluorophenyl)-2,4-dioxobutanoate 
• 6175-54-8 hydroxy-1-propyne 

Downstream Products

• 618383-48-5 3-(4-fluorophenyl)-1,2-oxazole-5-carboxylic acid 
• 1325228-73-6 C₁₂H₉ClFNO₃ 
• 1325228-75-8 C₁₀H₇ClFNO₂ 
• 1239576-23-8 4-chloro-3-(4-fluorophenyl)isoxazole-5-carboxylic acid 
• 1239576-09-0 4-chloro-3-(4-fluorophenyl)-N-((1R,3S)-3-hydroxycyclohexyl)isoxazole-5-carboxamide 
• 1421869-55-7 C₂₅H₂₉FN₄O*ClH 
• 1421869-67-1 C₂₅H₂₈ClFN₄O*ClH 
• 1421869-73-9 C₂₅H₂₈ClFN₄O*ClH 
• 1421869-79-5 C₂₆H₃₁FN₄O₂*ClH 
• 1421869-85-3 C₂₅H₂₈F₂N₄O*ClH 
• 1421869-91-1 C₃₂H₃₃F₃N₄O*ClH 
• 1421869-97-7 C₂₇H₃₃FN₄O*ClH 
• 1421870-03-2 C₂₅H₂₈ClFN₄O*ClH 
• 251912-65-9 3-(4-fluorophenyl)isoxazole-5-carbaldehyde 

Relevant articles and documents

Synthesis of novel 5-(3-alkylquinolin-2-yl)-3-aryl isoxazole derivatives and their cytotoxic activity

The propargyl alcohol on reaction with aldoxime and NaOCl in DCM gave exclusively (3-arylisoxazol-5-yl) methanol 1. The compound 1 was oxidized to an aldehyde 2 followed by reaction with aniline resulted in Schiff's base 3. The compounds 3 were further re

Ultrasonic-assisted synthesis of 1,4-disubstituted 1,2,3-triazoles via various terminal acetylenes and azide and their quorum sensing inhibition

An efficient synthesis of 1,4-disubstituted 1,2,3-triazole derivatives was studied. 1,4-Disubstituted 1,2,3-triazoles containing isoxazole and thymidine structures were synthesized in 84–96% yields starting from various terminal isoxazole ether alkynes and β-thymidine azide derivatives via a 1,3-dispolar cycloaddition using copper acetate, sodium ascorbate as the catalyst under ultrasonic assisted condition. All the target compounds were characterized by HRMS, FT-IR, 1H NMR and 13C NMR spectroscopy. Furthermore, the quorum sensing inhibitory activities of synthesized compounds were evaluated with Chromobacterium violaceum (C. Violaceum CV026) based on their inhibition of violacein production, with compound C10-HSL as a positive control. The compounds 8a, 8c and 8f exhibited considerable levels of inhibitory activity against violacein production, and IC50 values were 217?±?19, 223?±?20 and 42.8?±?4.5?μM, respectively, which highlighted the potential of these compounds as lead structures for further research towards the development of novel QS inhibitors.

Design and synthesis of a new series of 3,5-disubstituted isoxazoles active against Trypanosoma cruzi and Leishmania amazonensis

Chagas disease and leishmaniasis are neglected tropical diseases (NTDs) endemic in developing countries. Although there are drugs available for their treatment, efforts on finding new efficacious therapies are continuous. The natural lignans grandisin (1)