20696-64-4

Basic information

• Product Name: Z-TRP-NH2
• Synonyms: Z-L-TRYPTOPHAN AMIDE;Z-TRYPTOPHAN-NH2;Z-TRP-NH2;N-ALPHA-CARBOBENZOXY-L-TRYTOPHAN AMIDE;N-[(1S)-2-Amino-1-(1H-indol-3-ylmethyl)-2-oxoethyl]carbamic acid phenylmethyl ester;N-Carbobenzoxy-L-tryptophanamide;N-Cbz-L-tryptophanamide;Z-L-Trp-NH2
• CAS NO: 20696-64-4
• Molecular Formula: C₁₉H₁₉N₃O₃
• Molecular Weight: 337.37
• Mol File: 20696-64-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 188-189℃
• Appearance: /
• Density: 1.305
• Storage Temp.: Store at RT.
• Solubility: Acetic Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Z-TRP-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: Z-TRP-NH2(20696-64-4)
• EPA Substance Registry System: Z-TRP-NH2(20696-64-4)

Safety Data

• Hazardous Substances Data: 20696-64-4(Hazardous Substances Data)

Usage

Description

Z-TRP-NH2, also known as N-Carbobenzoxy-L-tryptophanamide, is a chemical compound that serves as an intermediate in the synthesis of L-Tryptophanamide Hydrochloride (T89550). It is a derivative of the amino acid tryptophan, with a carbobenzoxy (Z) protecting group and an amide functional group.

Uses

Used in Pharmaceutical Synthesis:
Z-TRP-NH2 is used as an intermediate in the pharmaceutical industry for the synthesis of L-Tryptophanamide Hydrochloride (T89550). Z-TRP-NH2 is important in the development of various pharmaceutical products, particularly those related to the treatment of certain medical conditions.
Used in Research and Development:
In the field of research and development, Z-TRP-NH2 is utilized as a key component in the synthesis of various tryptophan-based compounds. Its role in the creation of these compounds aids in the advancement of scientific understanding and the development of new therapeutic agents.
Used in Chemical Synthesis:
Z-TRP-NH2 is also used as a building block in the chemical synthesis of various tryptophan-containing compounds. Its unique structure allows for the creation of a wide range of molecules with potential applications in different industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 7432-21-5 N-carbobenzyloxy-L-tryptophane 
• 133641-28-8 Z-Trp-O-COO-isoBu 
• 50305-28-7 Cbz-L-Tryptophan-OSu 

Downstream Products

• 20696-57-5 L-tryptophanamide 
• 5022-65-1 L-tryptophanamide hydrochloride 
• 1219039-97-0 Nα-[3-(2-fluorophenyl)acryloyl]-L-tryptophanamide 
• 1596353-92-2 (S)-tert-butyl 2-((S)-2-(benzyloxy)carbonylamino-3-(1H-indol-3-yl)propionylamino)hex-3-enoate 

Relevant articles and documents

The Synthesis of Cystine Peptides by Iodine Oxidation of S-Trityl-cysteine and S-Acetamidomethyl-cysteine Peptides

Previously repoted studies of the iodine oxidation of S-trityl-cysteine peptides and S-acetamidomethyl-cysteine peptides, leading directly to cystine peptides, have been extended.Detailed investigations have been made of the reactivities of the S-trityl a

AMINO ACID DERIVATIVE

The amino acid derivative of the present invention provides a novel compound that shows excellent analgesic action. The amino acid derivative of the present invention is a novel compound that shows excellent analgesic action to not only a model animal for nociceptive pains but also a model animal for neuropathic pains, so that the amino acid derivative is very useful as a drug for treating various pain diseases.

New active series of growth hormone secretagogues

New growth hormone secretagogue (GHS) analogues were synthesized and evaluated for growth hormone releasing activity. This series derived from EP-51389 is based on a gem-diamino structure. Compounds that exhibited higher in vivo GH-releasing potency than hexarelin in rat (subcutaneous administration) were then tested per os in beagle dogs and for their binding affinity to human pituitary GHS receptors and to hGHS-R 1a. Compound 7 (JMV 1843, H-Aib-(D)-Trp-(D)-gTrp-formyl) showed high potency in these tests and was selected for clinical studies.