207115-38-6

Basic information

• Product Name: BENZOIC ACID, 3-IODO-4-METHOXY-, ETHYL ESTER
• Synonyms: BENZOIC ACID, 3-IODO-4-METHOXY-, ETHYL ESTER;ETHYL 3-IODO-4-METHOXYBENZOATE;3-Iodo-4-methoxy-benzoic acid ethyl ester
• CAS NO: 207115-38-6
• Molecular Formula: C₁₀H₁₁IO₃
• Molecular Weight: 306.094
• Mol File: 207115-38-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 352.7 °C at 760 mmHg
• Flash Point: 167.1 °C
• Appearance: /
• Density: 1.611 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: BENZOIC ACID, 3-IODO-4-METHOXY-, ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: BENZOIC ACID, 3-IODO-4-METHOXY-, ETHYL ESTER(207115-38-6)
• EPA Substance Registry System: BENZOIC ACID, 3-IODO-4-METHOXY-, ETHYL ESTER(207115-38-6)

Safety Data

• Hazardous Substances Data: 207115-38-6(Hazardous Substances Data)

Usage

General Description

BENZOIC ACID, 3-IODO-4-METHOXY-, ETHYL ESTER is an organic compound that belongs to the ester group of chemicals. It is derived from benzoic acid, which is commonly found in certain plants and used as a food preservative. This specific compound contains an ethyl ester group, which is a common functional group in organic chemistry, and an iodo-methoxy substituent. It is commonly used in the pharmaceutical and chemical industries for various purposes, including as a reagent in organic synthesis and as an intermediate in the production of other compounds. Additionally, it may have potential applications in the development of new drugs and materials.

Upstream product

• 64-17-5 ethanol 
• 68507-19-7 3-iodo-4-methoxybenzoic acid 
• 4253-10-5 methyl 3,5-diiodo-4-methoxybenzoate 
• 3337-66-4 methyl 4-hydroxy-3,5-diiodobenzoate 
• 15126-07-5 4-hydroxy-3-iodo-benzoic acid ethyl ester 
• 74-88-4 methyl iodide 

Downstream Products

• 105401-94-3 ethyl 4-methoxy-3,5-dimethylbenzoate 

Relevant articles and documents

Pd-Catalyzed ipso, meta-Dimethylation of ortho-Substituted Iodoarenes via a Base-Controlled C-H Activation Cascade with Dimethyl Carbonate as the Methyl Source

A methyl group can have a profound impact on the pharmacological properties of organic molecules. Hence, developing methylation methods and methylating reagents is essential in medicinal chemistry. We report a palladium-catalyzed dimethylation reaction of ortho-substituted iodoarenes using dimethyl carbonate as a methyl source. In the presence of K2CO3 as a base, iodoarenes are dimethylated at the ipso- and meta-positions of the iodo group, which represents a novel strategy for meta-C-H methylation. With KOAc as the base, subsequent oxidative C(sp3)-H/C(sp3)-H coupling occurs; in this case, the overall transformation achieves triple C-H activation to form three new C-C bonds. These reactions allow expedient access to 2,6-dimethylated phenols, 2,3-dihydrobenzofurans, and indanes, which are ubiquitous structural motifs and essential synthetic intermediates of biologically and pharmacologically active compounds.