207233-90-7

Basic information

• Product Name: 4 4'-DIISOTHIOCYANATO-2 2'-STILBENEDISU&
• Synonyms: 4 4'-DIISOTHIOCYANATO-2 2'-STILBENEDISU&;4,4'-DIISOTHIOCYANATO-2,2'-STILBENEDISUL -FONIC ACID, DI-NA SALT XH2O TECH., 90%;4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid disodium salt hydrate;4,4''-DIISOTHIOCYANATOSTILBENE-2,2''-DISULPHONIC ACID DISODIUM SALT;4,4μ-Diisothiocyanato-2,2μ-stilbenedisulfonic acid hydrate disodium salt;4,4μ-Diisothiocyanatostilbene-2,2μ-disulfonic acid hydrate disodium salt;DIDS, Disodium 4,4μ-diisothiocyanatostilbene-2,2μ-disulfonate;4,4'-Diisothiocyanatostilbene-2,2'-disulphonic acid disodium salt hydrate
• CAS NO: 207233-90-7
• Molecular Formula: C16H8N2O6S4.2Na
• Molecular Weight: 498.491
• Product Categories: homoXlink
• Mol File: 207233-90-7.mol
• Article Data: 0

Chemical Properties

• Appearance: yellow/
• Storage Temp.: Store at 2-8
• Solubility: 0.1 M potassium bicarbonate: soluble50mg/mL
• BRN: 8179433
• CAS DataBase Reference: 4 4'-DIISOTHIOCYANATO-2 2'-STILBENEDISU&(CAS DataBase Reference)
• NIST Chemistry Reference: 4 4'-DIISOTHIOCYANATO-2 2'-STILBENEDISU&(207233-90-7)
• EPA Substance Registry System: 4 4'-DIISOTHIOCYANATO-2 2'-STILBENEDISU&(207233-90-7)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-42
• Safety Statements: 22-26
• WGK Germany: 3
• Hazardous Substances Data: 207233-90-7(Hazardous Substances Data)

Usage

Description

4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid disodium salt hydrate, also known as DIDS, is a chemical compound that acts as a potent inhibitor of anion exchangers and transporters. It is characterized by its ability to bind to specific proteins and inhibit their function, making it a valuable tool in biological research and therapeutic applications.

Uses

Used in Pharmaceutical Research:
4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid disodium salt hydrate is used as a band3 protein inhibitor in rabbits for the inhibition of bicarbonate transporters in brain slice tissue. This application aids in understanding the role of bicarbonate transport in various physiological processes and potential therapeutic targets for related disorders.
Used in Embryonic Development Studies:
In the field of embryonic development, 4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid disodium salt hydrate is used as an HCO3-/Clexchanger (anion exchanger) in embryos. This helps researchers investigate the role of anion exchange in embryonic development and identify potential targets for therapeutic intervention.
Overall, 4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid disodium salt hydrate is a versatile compound with applications in various scientific and medical fields, primarily due to its ability to inhibit specific transporters and exchangers, providing valuable insights into their functions and potential therapeutic uses.

Biochem/physiol Actions

4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid is an anionic alkylating agent containing isothiocyanate residue. It is a negatively charged homobifunctional cross-linking reagent. 4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid is a specific inhibitor of cellular anion permeability used in cell transport studies. The isothiocyanate groups react with primary amines at pH 9.0-10.0. 4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid alkylates lysine residues and inhibits apoptosis indirectly by targeting membrane based anion transporters.In addition, it also inhibits calcium transport in vesicles.