20730-99-8

Basic information

• Product Name: 2,6-dimethylphenylphthalimide
• Synonyms: 2,6-dimethylphenylphthalimide
• CAS NO: 20730-99-8
• Molecular Formula: C₁₆H₁₃NO₂
• Molecular Weight: 251.28
• Mol File: 20730-99-8.mol
• Article Data: 14

Chemical Properties

• Melting Point: 204 °C(Solv: ethanol (64-17-5))
• Boiling Point: 407.3°Cat760mmHg
• Flash Point: 183.7°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 7.62E-07mmHg at 25°C
• Refractive Index: 1.639
• PKA: 0.82±0.20(Predicted)
• CAS DataBase Reference: 2,6-dimethylphenylphthalimide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dimethylphenylphthalimide(20730-99-8)
• EPA Substance Registry System: 2,6-dimethylphenylphthalimide(20730-99-8)

Safety Data

• Hazardous Substances Data: 20730-99-8(Hazardous Substances Data)

Usage

Physical form

White crystalline solid

Primary use

Chemical intermediate in the production of other organic compounds

Common applications

Synthesis of pharmaceuticals, agrochemicals, and dyes

Utility

Reagent in organic chemistry, particularly in the preparation of various aromatic derivatives

Significance

Important role in the development and production of a wide range of chemical products

InChI:InChI=1/C16H13NO2/c1-10-6-5-7-11(2)14(10)17-15(18)12-8-3-4-9-13(12)16(17)19/h3-9H,1-2H3

Upstream product

• 85-44-9 phthalic anhydride 
• 87-62-7 2,6-dimethylaniline 
• 136918-14-4 phthalimide 
• 108-38-3 m-xylene 
• 3481-09-2 N-chlorophthalimide 
• 83-33-0 inden-1-one 
• 7677-24-9 trimethylsilyl cyanide 
• 88-67-5 2-Iodobenzoic acid 

Downstream Products

• 113439-96-6 2-(2,6-dimethylphenyl)isoindoline 
• 134750-55-3 2-hydroxymethyl-benzoic acid-(2,6-dimethyl-anilide) 
• 802971-38-6 N-(2,6-bis-trichloromethyl-phenyl)-phthalimide 
• 122679-12-3 2-(2,6-dimethyl-anilinomethyl)-benzyl alcohol 
• 119077-36-0 2-(phenylcarbamoyloxy-methyl)-benzoic acid-(2,6-dimethyl-anilide) 
• 109700-55-2 2-(2,6-dimethyl-phenyl)-2-methyl-isoindolinium; iodide 

Relevant articles and documents

“On water” nano-Cu2O-catalyzed CO-free one-pot multicomponent cascade cyanation-annulation-aminolysis reaction toward phthalimides

An efficient nano-Cu2O-catalyzed cascade multicomponent reaction of 2-halobenzoic acids and trimethylsilyl cyanide with diverse amines was developed using water as a solvent, affording versatileN-substituted phthalimide derivatives in moderate to excellent yields. This novel strategy features carbon monoxide gas-free, environmentally benign, one-pot multistep transformation, commercially available reagents, a cheap catalyst without any additives, wide functional group tolerance, and operational convenience.

Palladium Catalyzed Regioselective Synthesis of Substituted Biaryl Amides through Decarbonylative Arylation of Phthalimides

The Pd(OAc)2 catalyzed cross-coupling of N-substituted phthalimides with aryl halide provides a single step direct access of a wide range of synthetically appealing ortho-substituted biarylamides in high yields through unique carbonyl (CO) replacement. The reaction proceeds through a ligand-free condition and is well tolerant to the diverse functionality of both imide and halide units. The reaction negates any requirement of organometallic reagent and needs a shorter reaction time and comparatively lower temperature as required for previously reported decarbonylative processes.

Synthetic method for N-substituted imide

The invention provides a synthetic method for N-substituted imide. According to the method, aromatic ketone and amine are used as substrates, air or oxygen is used as an oxygen source, and cyclic imide is produced under liquid phase conditions under the action of a catalyst. The method is mild in conditions, high in oxidation efficiency and high in product yield; and since the method uses air or oxygen as the oxygen source, the method is economic and environment-friendly and has good application prospect.