2077-19-2

Basic information

• Product Name: 2-(4-BROMOPHENYL)PROPAN-2-OL
• Synonyms: 2-(4-BROMOPHENYL)PROPAN-2-OL;2-(4-BroMophenyl)-2-propanol;4-Bromophenyldimethylcarbinol;p-Bromo-alpha,alpha-dimethylbenzyl alcohol;p-Bromocumyl alcohol
• CAS NO: 2077-19-2
• Molecular Formula: C₉H₁₁BrO
• Molecular Weight: 215.08704
• Mol File: 2077-19-2.mol
• Article Data: 48

Chemical Properties

• Melting Point: 45.6℃
• Boiling Point: 75-85℃ /0.1mm
• Flash Point: 124.068 °C
• Appearance: White/Solid
• Density: 1.356
• Refractive Index: 1.5520
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.29±0.29(Predicted)
• Water Solubility: Slightly soluble in water (1.4 g/L) (25°C)
• CAS DataBase Reference: 2-(4-BROMOPHENYL)PROPAN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-BROMOPHENYL)PROPAN-2-OL(2077-19-2)
• EPA Substance Registry System: 2-(4-BROMOPHENYL)PROPAN-2-OL(2077-19-2)

Safety Data

• Hazardous Substances Data: 2077-19-2(Hazardous Substances Data)

Usage

Description

2-(4-Bromophenyl)propan-2-ol, also known as Bromophenol, is an organic compound characterized by the presence of a bromine atom attached to a phenyl group and a secondary alcohol functional group. It is a colorless to pale yellow liquid with a distinctive aromatic odor. 2-(4-Bromophenyl)propan-2-ol is known for its reactivity and is widely utilized in various chemical and pharmaceutical applications due to its unique structural features.

Uses

Used in Organic Synthesis:
2-(4-Bromophenyl)propan-2-ol is used as a key intermediate in the synthesis of various organic compounds. Its bromine atom can be easily replaced by other functional groups, making it a versatile building block for the creation of a wide range of molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(4-Bromophenyl)propan-2-ol is used as a crucial intermediate for the development of new drugs. Its unique structure allows for the formation of various medicinally relevant compounds, contributing to the advancement of drug discovery and development.
Used in Agrochemicals:
2-(4-Bromophenyl)propan-2-ol is also utilized in the agrochemical industry as a starting material for the synthesis of various agrochemical products. Its reactivity and structural properties make it suitable for the development of new pesticides, herbicides, and other agricultural chemicals.
Used in Dyestuffs:
In the dyestuffs industry, 2-(4-Bromophenyl)propan-2-ol is employed as an important raw material for the production of various dyes and pigments. Its ability to form a wide range of derivatives makes it a valuable component in the synthesis of colorants for various applications, including textiles, plastics, and printing inks.
Used as a Medicine Intermediate:
2-(4-Bromophenyl)propan-2-ol is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structural features enable the development of new drugs with potential therapeutic applications, making it an essential component in the pharmaceutical industry's efforts to create novel and effective medications.

Upstream product

• 5798-75-4 Ethyl 4-bromobenzoate 
• 18620-02-5 (4-bromophenyl)magnesium bromide 
• 67-64-1 acetone 
• 75-16-1 methylmagnesium bromide 
• 99-90-1 para-bromoacetophenone 
• 917-64-6 methyl magnesium iodide 
• 35658-88-9 tert-butyl p-bromo-α,α-dimethylbenzyl peroxide 
• 106-37-6 1.4-dibromobenzene 
• 586-61-8 4-iso-propylbromobenzene 
• 917-54-4 methyllithium 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 6888-79-5 4-bromo-α-methylstyrene 
• 676-58-4 methylmagnesium chloride 
• 1261174-44-0 C₁₅H₁₅BrS 

Downstream Products

• 6888-79-5 4-bromo-α-methylstyrene 
• 14276-98-3 2-(4-bromophenyl)-2-chloropropane 
• 35658-88-9 tert-butyl p-bromo-α,α-dimethylbenzyl peroxide 
• 88519-64-6 2,5-dimethyl-2,5-bis(p-bromo-α,α-dimethylbenzylperoxy)-3-hexyne 
• 79143-36-5 1,1-dimethyl-2-propynyl p-bromo-α,α-dimethylbenzyl peroxide 
• 88519-63-5 2-methyl-2-(p-bromo-α,α-dimethylbenzylperoxy)-5-hexen-3-yne 
• 106-41-2 4-bromo-phenol 
• 90862-07-0 Phenyl-carbamic acid 1-(4-bromo-phenyl)-1-methyl-ethyl ester 
• 90862-23-0 p-Tolyl-carbamic acid 1-(4-bromo-phenyl)-1-methyl-ethyl ester 
• 90862-25-2 Carbonic acid 1-(4-bromo-phenyl)-1-methyl-ethyl ester phenyl ester 
• 37446-16-5 1-[1-(4-Bromo-phenyl)-1-methyl-ethoxy]-2,4-dinitro-benzene 
• 61776-65-6 1-bromo-4-(2-bromopropan-2-yl)benzene 
• 56924-31-3 2-(4-Bromphenyl)-2-(4-methoxyphenyl)-propan 
• 376646-65-0 4-(4-bromophenyl)nicotinaldehyde 

Relevant articles and documents

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Palladium-Aminopyridine Catalyzed C?H Oxygenation: Probing the Nature of Metal Based Oxidant

A mechanistic study of direct selective oxidation of benzylic C(sp3)?H groups with peracetic acid, catalyzed by palladium complexes with tripodal amino-tris(pyriylmethyl) ligands, is presented. The oxidation of arylalkanes having secondary and tertiary benzylic C?H groups, predominantly yields, depending on the substrate and conditions, either the corresponding ketones or alcohols. One of the three 2-pyriylmethyl moieties, which is pending in the starting catalyst, apparently, facilitates the active species formation and takes part in stabilization of the high-valent Pd center in the active species, occupying the axial coordination site of palladium. The catalytic, as well as isotopic labeling experiments, in combination with ESI-MS data and DFT calculations, point out palladium oxyl species as possible catalytically active sites, operating essentially via C?H abstraction/oxygen rebound pathway. For the ketones formation, O?H abstraction/в-scission mechanism has been proposed.

Efficient and selective oxidation of tertiary benzylic C[sbnd]H bonds with O2 catalyzed by metalloporphyrins under mild and solvent-free conditions

The direct and efficient oxidation of tertiary benzylic C[sbnd]H bonds to alcohols with O2 was accomplished in the presence of metalloporphyrins as catalysts under solvent-free and additive-free conditions. Based on effective inhibition on the unselective autoxidation and deep oxidation, systematical investigation on the effects of porphyrin ligands and metal centers, and apparent kinetics study, the oxidation system employing porphyrin manganese(II) (T(2,3,6-triCl)PPMn) with bulkier substituents as catalyst, was regarded as the most promising and efficient one. For the typical substrate, the conversion of cumene could reach up to 57.6% with the selectivity of 70.5% toward alcohol, both of them being higher than the current documents under similar conditions. The superiority of T(2,3,6-triCl)PPMn was mainly attributed to its bulkier substituent groups preventing metalloporphyrins from oxidative degradation, its planar structure favoring the interaction between central metal with reactants, and the high efficiency of Mn(II) in the catalytic transformation of hydroperoxides to alcohols.