20788-07-2

Basic information

• Product Name: Resorantel
• Synonyms: RESORANTEL;Pesorantelum;N-(4-Bromophenyl)-2,6-dihydroxybenzamide
• CAS NO: 20788-07-2
• Molecular Formula: C₁₃H₁₀BrNO₃
• Molecular Weight: 308.13
• EINECS: 244-040-9
• Mol File: 20788-07-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 229-230°; mp 183-186° (LeMaire)
• Boiling Point: 391.1°Cat760mmHg
• Flash Point: 190.4°C
• Appearance: /
• Density: 1.699g/cm³
• Vapor Pressure: 1.12E-06mmHg at 25°C
• Refractive Index: 1.728
• Storage Temp.: 2-8°C
• PKA: 7.62±0.35(Predicted)
• CAS DataBase Reference: Resorantel(CAS DataBase Reference)
• NIST Chemistry Reference: Resorantel(20788-07-2)
• EPA Substance Registry System: Resorantel(20788-07-2)

Safety Data

• Hazardous Substances Data: 20788-07-2(Hazardous Substances Data)

Usage

General Description

Resorantel is a systemic anthelmintic agent that is used in the treatment of parasitic infections caused by various types of roundworms and hookworms. It works by interfering with the energy metabolism of the parasites, leading to their paralysis and subsequent expulsion from the body. Resorantel is commonly used in veterinary medicine to treat parasitic infections in animals, particularly in livestock such as sheep and cattle. It is also sometimes used in combination with other anthelmintic drugs to provide broad-spectrum treatment against different types of parasites. Adverse effects of Resorantel may include gastrointestinal disturbances, such as diarrhea and vomiting, as well as potential allergic reactions. As with any medication, it should be used with caution and under the guidance of a veterinarian or medical professional.

InChI:InChI=1/C13H10BrNO3/c14-8-4-6-9(7-5-8)15-13(18)12-10(16)2-1-3-11(12)17/h1-7,16-17H,(H,15,18)

Upstream product

• 303-07-1 2,6-Dihydroxybenzoic acid 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 50505-15-2 N-(4-Bromo-phenyl)-3,5-dichloro-2,6-dihydroxy-benzamide 
• 50505-16-3 3,5-Dibromo-N-(4-bromo-phenyl)-2,6-dihydroxy-benzamide 
• 31914-63-3 3-Acetyl-N-(4-bromo-phenyl)-2,6-dihydroxy-benzamide 
• 31914-62-2 N-(4-Bromo-phenyl)-3-hexanoyl-2,6-dihydroxy-benzamide 
• 31936-03-5 N-(4-Bromo-phenyl)-2,6-dihydroxy-3-isobutyryl-benzamide 
• 31914-61-1 N-(4-Bromo-phenyl)-3-butyryl-2,6-dihydroxy-benzamide 
• 50505-20-9 3-Acetyl-N-(4-bromo-phenyl)-5-chloro-2,6-dihydroxy-benzamide 
• 50505-19-6 3-Acetyl-5-bromo-N-(4-bromo-phenyl)-2,6-dihydroxy-benzamide 
• 50505-18-5 3-Acetyl-N-(4-bromo-phenyl)-2,6-dihydroxy-5-iodo-benzamide 
• 51754-68-8 N-(4-Bromo-phenyl)-3-butyl-2,6-dihydroxy-benzamide 
• 51754-71-3 N-(4-Bromo-phenyl)-3-butyryl-2,6-dihydroxy-5-iodo-benzamide 

Relevant articles and documents

2,6 Dihydroxybenzoic acid derivatives as anthelmintics

The 2,6 dihydroxybenzoic acid anilides have marked cesticidal properties when a specific form of substitution by halogen atoms or methyl groups is made in the anilide portion of the molecule. Optimum activity is achieved with 2,6 dihydroxybenzoic acid 4' bromanilide. This compound interferes with the energy metabolism of cestodes, inhibiting the breakdown of glucose and lowering the ATP level. The introduction of halogen atoms in the 3 and 5 position of the benzoic acid portion increases the activity but the toxicity as well. Activity against the liver fluke is also observed and prevails when an electronegative substituent is introduced in the 3 position. The most effective compounds are the 3 nitro 2,6 dihydroxybenzoic acid anilides, followed by the 3 acyl 2,6 dihydroxybenzoic acid anilides. The choice of substituents in the anilide portion is restricted to halogens, methyl groups, tri halogenated methyls, i.e. substituents which improve the lipoid solubility. Optimum efficacy is achieved with 3 nitro 2,6 dihydroxybenzoic acid 3',5' bis trifluoromethyl anilide. A description of the chemical methods of synthesis is given.