20807-99-2

Basic information

• Product Name: ETHYL THIOBUTYRATE
• Synonyms: ETHYL THIOBUTYRATE
• CAS NO: 20807-99-2
• Molecular Formula: C₆H₁₂OS
• Molecular Weight: 132.22
• Product Categories: API intermediates
• Mol File: 20807-99-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 164.9 °C at 760 mmHg
• Flash Point: 48.8 °C
• Appearance: /
• Density: 0.953 g/cm³
• CAS DataBase Reference: ETHYL THIOBUTYRATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL THIOBUTYRATE(20807-99-2)
• EPA Substance Registry System: ETHYL THIOBUTYRATE(20807-99-2)

Safety Data

• Hazardous Substances Data: 20807-99-2(Hazardous Substances Data)

Usage

General Description

Ethyl thiobutyrate is a chemical compound with the molecular formula C6H12OS. It is a clear, colorless liquid with a pungent, fruity odor, reminiscent of grapefruit. Ethyl thiobutyrate is commonly used as a flavor and fragrance agent in the food and beverage industry, adding a sweet and fruity aroma to various products. It is also used in the production of perfumes and other cosmetic products. Additionally, ethyl thiobutyrate is a potential natural volatile compound found in grapes and wines, contributing to the overall aroma and flavor profile of these products. However, the chemical should be handled with caution as it can be irritating to the eyes, skin, and respiratory system.

Upstream product

• 141-75-3 butyryl chloride 
• 811-51-8 sodium thioethylate 
• 27001-65-6 2-propyl-1,3-oxathiolan 
• 75-08-1 ethanethiol 
• 70166-15-3 1-bromo-2-<(ethylthio)carbonyl>propane 
• 5309-97-7 1--butanethione 
• 75-03-6 ethyl iodide 
• 2635-84-9 p-nitrophenyl butyrate 

Downstream Products

• 110-39-4 n-octyl butyrate 
• 95954-10-2 Triphenylphosphin-<1-butyryl-aethylen> 
• 638-11-9 isopropyl butyrate 
• 14252-32-5 1-phenyl-hex-1-yn-3-one 
• 107-92-6 butyric acid 

Relevant articles and documents

A Mild Method for Access to α-Substituted Dithiomalonates through C-Thiocarbonylation of Thioester: Synthesis of Mesoionic Insecticides

An efficient method for targeting a variety of symmetrical and asymmetrical α-substituted dithiomalonates (DTMs) is described, utilizing 1H-imidazole-1-carbothioates as reactive acylating agents and MgBr2?OEt2/DBU or LiHMDS for soft or hard enolization conditions of thioesters, respectively. The utility of this methodology was demonstrated through the synthesis of the pyridopyrimidine mesoionic insecticides: triflumezopyrim and dicloromezotiaz. (Figure presented.).

A simple and direct method for converting thioamides into thioesters

Thioamides may be transformed into thioesters through the simple expedient of warming them in an aqueous THF solution containing an alkylating agent. Reactions proceed in high yield and are amenable to multi-gram scale.

ACTIVITY OF 1-OXA-3-THIACYCLOALKANES AND 2-ALKYLTHIOOXACYCLANES IN FREE-RADICAL ISOMERIZATION

It was established that radical isomerization to alkyl esters of thiocarboxylic acids, initiated by tert-butyl peroxide at 130-150 deg C, is a common reaction for five-, six- and seven-membered 1-oxa-3-thiacycloalkanes and 2-alkylthiooxacycloalkanes.Under analogous conditions 2-diethylaminotetrahydropyran isomerizes to N,N-diethylvaleramide.The relation between the structure and the reactivity of 1-oxa-3-thiacycloalkanes and 2-alkylthiooxacycloalkanes in free-radical isomerisation was studied by the method of competing reactions.Depending on the ring size, the activity of the 1-oxa-3-thiacycloalkanes increases in the order : 1,3-oxathianes 1,3-oxathiolanes 1,3-oxathiepanes.