208331-49-1

Basic information

• Product Name: Silane, [[(2E)-1,3-diphenyl-1-(trifluoromethyl)-2-propenyl]oxy]trimethyl-
• CAS NO: 208331-49-1
• Molecular Formula: C19H21F3OSi
• Molecular Weight: 350.456
• Mol File: 208331-49-1.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Silane, [[(2E)-1,3-diphenyl-1-(trifluoromethyl)-2-propenyl]oxy]trimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, [[(2E)-1,3-diphenyl-1-(trifluoromethyl)-2-propenyl]oxy]trimethyl-(208331-49-1)
• EPA Substance Registry System: Silane, [[(2E)-1,3-diphenyl-1-(trifluoromethyl)-2-propenyl]oxy]trimethyl-(208331-49-1)

Safety Data

• Hazardous Substances Data: 208331-49-1(Hazardous Substances Data)

Upstream product

• 75-46-7 trifluoromethan 
• 1586-73-8 tris(trimethylsilyl)amine 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 94-41-7 benzalacetophenone 
• 497937-79-8 N-trifluoromethanesulfinyl-O-trimethylsilylephedrine 
• 497937-77-6 N-trifluoroacetyl-O-trimethylsilylephedrine 
• 289706-46-3 4-[2,2,2-trifluoro-1-(trimethylsilyloxy)ethyl]morpholine 

Downstream Products

• 208331-48-0 1-(trans)-phenylethenyl-1-phenyl-trifluoromethylcarbinol 

Relevant articles and documents

MgCl2-catalyzed trifluoromethylation of carbonyl compounds using (trifluoromethyl)trimethylsilane as the trifluoromethylating agent

Using (trifluoromethyl)trimethylsilane (TMSCF3) as the trifluoromethylating agent, MgCl2-catalyzed trifluoromethylation of carbonyl compounds proceeded readily at room temperature. In the presence of 10 mol% of MgCl2, a variety of carbonyl substrates such as aliphatic/aromatic aldehydes, acyclic/cyclic ketones and esters could be trifluoromethylated in DMF, giving the corresponding trimethylsilyl ethers (ketals) in up to 93% isolated yields. Trifluoromethylketones could be readily obtained after hydrolysis of the trimethylsilyl ketals. The reactions could tolerate air and moisture, and the use of oxygen and moisture-free conditions was not required.

Tetraarylphosphonium inner-salts (TAPIS) as both Lewis base catalyst and phase tag

Tetraarylphosphonium inner-salts (TAPIS) have been designed, synthesized and verified as recyclable and reusable Lewis base catalysts. The resulted TAPIS catalyst has been successfully applied in Michael addition, cyanation and trifluoromethylation reactions.

TTMPP-catalyzed trifluoromethylation of carbonyl compounds and imines with trifluoromethylsilane

A highly basic phosphine, tris(2,4,6-trimethoxyphenyl)phosphine (TTMPP), catalyzes trifluoromethylation using trifluoromethyltrimethylsilane to give the corresponding trifluoromethylated products in good to high yields, with both carbonyl compounds and im