208533-37-3

Basic information

• Product Name: 4-CHLOROQUINAZOLIN-6-AMINE
• Synonyms: 4-CHLOROQUINAZOLIN-6-AMINE;4-chloroquinazolin-6-amine hydrochloride;4-Chloroquinazolin-6-ylamine;6-AMino-4-chloroquinazoline HCl;6-QUINAZOLINAMINE, 4-CHLORO-;4-CHLOROQUIZOLIN-6-AMINE
• CAS NO: 208533-37-3
• Molecular Formula: C₈H₆ClN₃
• Molecular Weight: 179.61
• Product Categories: CHIRAL CHEMICALS
• Mol File: 208533-37-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 370.4 °C at 760 mmHg
• Flash Point: 177.8 °C
• Appearance: /
• Density: 1.445 g/cm³
• Storage Temp.: 2-8°C
• PKA: 1.17±0.10(Predicted)
• CAS DataBase Reference: 4-CHLOROQUINAZOLIN-6-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLOROQUINAZOLIN-6-AMINE(208533-37-3)
• EPA Substance Registry System: 4-CHLOROQUINAZOLIN-6-AMINE(208533-37-3)

Safety Data

• Hazardous Substances Data: 208533-37-3(Hazardous Substances Data)

Usage

General Description

4-Chloroquinazolin-6-amine is a chemical compound with the molecular formula C8H6ClN3. It is a chlorine-substituted derivative of quinazoline and is classified as an amine. This chemical is commonly used as a building block in the synthesis of various pharmaceutical and agrochemical compounds. It has been studied for its potential use in the treatment of cancer, as it has shown inhibitory effects on certain enzymes and cell growth. Additionally, 4-chloroquinazolin-6-amine has also been investigated for its potential use as an intermediate in the production of dyes and other specialty chemicals.

InChI:InChI=1/C8H6ClN3.ClH/c9-8-6-3-5(10)1-2-7(6)11-4-12-8;/h1-4H,10H2;1H

Upstream product

• 19815-16-8 4-chloro-6-nitro-quinazoline 

Relevant articles and documents

SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS

This invention provides compounds of formula (1) wherein X is C3-7 cycloalkyl, pyridinyl, pyrimidinyl or phenyl ring optionally substituted as described in claim 1, R1, R3 and R4 are chosen from the groups listed in claim 1. R2 is chosen from various unsaturated acyl groups listed in claim 1, with certain compounds being disclaimed. Use as tyrosine kinase inhibitors for the treatment of cancer and certain kidney diseases such as polycystic kidney disease.

Substituted quinazoline derivatives

This invention provides compounds of formula 1 having the structure wherein: X, R1, R2, R3, R4, Z, X, and n are as defined hereinbefore in the specification, which are useful as antineoplastic agents and in the treatment of certain kidney diseases, such as polycystic kidney disease.

Method of treating polycystic kidney disease

This invention provides a method of treating or inhibiting polycystic kidney disease in a mammal in need thereof which comprises administering to said mammal a compound having the formula STR1 wherein: X is phenyl which is optionally substituted; R and R1 are each, independently, hydrogen, halogen, alkyl, alkoxy, hydroxy, or trifluoromethyl; R2 is hydrogen, alkyl, alkoxy, hydroxy, trifluoromethyl; Y is a radical selected from the group consisting of STR2 R3 is independently hydrogen, alkyl, carboxy, carboalkoxy, phenyl, or carboalkyl; n=2-4; or a pharmaceutically acceptable salt thereof, with the proviso that each R3 of Y may be the same or different.