20904-57-8

Basic information

• Product Name: N,N-dimethyl-3-phenoxypropan-1-amine
• Synonyms: 1-Propanamine, N,N-dimethyl-3-phenoxy-; N,N-Dimethyl-3-phenoxy-1-propanamine; N,N-Dimethyl-3-phenoxypropan-1-amine; N,N-Dimethyl-3-phenoxypropylamine
• CAS NO: 20904-57-8
• Molecular Formula: C₁₁H₁₇NO
• Molecular Weight: 179.2588
• Mol File: 20904-57-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 258°C at 760 mmHg
• Flash Point: 75.5°C
• Density: 0.96g/cm³
• Vapor Pressure: 0.0141mmHg at 25°C
• Refractive Index: 1.502
• CAS DataBase Reference: N,N-dimethyl-3-phenoxypropan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-3-phenoxypropan-1-amine(20904-57-8)
• EPA Substance Registry System: N,N-dimethyl-3-phenoxypropan-1-amine(20904-57-8)

Safety Data

• Hazardous Substances Data: 20904-57-8(Hazardous Substances Data)

Upstream product

• 108847-05-8 trimethyl-(3-phenoxy-propyl)-ammonium; iodide 
• 588-63-6 3-phenoxypropyl bromide 
• 124-40-3 dimethyl amine 
• 139-02-6 sodium phenoxide 
• 83698-50-4 Trifluoro-methanesulfonate1-(3-dimethylamino-propyl)-2,4,6-triphenyl-pyridinium; 
• 109-54-6 3-(Dimethylamino)propyl chloride 
• 108-95-2 phenol 
• 109-55-7 1-amino-3-(dimethylamino)propane 
• 3179-63-3 3-Dimethylamino-1-propanol 
• 105-58-8 Diethyl carbonate 

Downstream Products

• 53929-74-1 N,N-dimethyl-3-bromopropylamine 
• 109-54-6 3-(Dimethylamino)propyl chloride 
• 108-95-2 phenol 
• 20904-18-1 N,N-dimethyl-3-phenoxypropan-1-amine hydrochloride 

Relevant articles and documents

Mustard Carbonate Analogues as Sustainable Reagents for the Aminoalkylation of Phenols

N,N-dialkyl ethylamine moiety can be found in numerous scaffolds of macromolecules, catalysts, and especially pharmaceuticals. Common synthetic procedures for its incorporation in a substrate relies on the use of a nitrogen mustard gas or on multistep syntheses featuring chlorine hazardous/toxic chemistry. Reported herein is a one-pot synthetic approach for the easy introduction of aminoalkyl chain into different phenolic substrates through dialkyl carbonate (β-aminocarbonate) chemistry. This new direct alcohol substitution avoids the use of chlorine chemistry, and it is efficient on numerous pharmacophore scaffolds with good to quantitative yield. The cytotoxicity via MTT of the β-aminocarbonate, key intermediate of this synthetic approach, was also evaluated and compared with its alcohol precursor.

SALTS OF INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE

Disclosed herein are salts of carbonyl compounds as inhibitors of histone deacetylase (HDAC), useful in treating disease states including cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis,

Pyridiniums as potential synthetic substitutes for nitrogen mustards

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