2091-46-5 Usage
Description
PROPARGYLTRIPHENYLPHOSPHONIUM BROMIDE is a white to slightly yellow fine crystalline powder, commonly known as a Wittig reagent. It is a phosphonium salt that is widely utilized in organic chemistry for various applications due to its unique chemical properties.
Uses
Used in Organic Chemistry:
PROPARGYLTRIPHENYLPHOSPHPHONIUM BROMIDE is used as a Wittig reagent for the alkylation of amines. It serves as a valuable tool in the synthesis of various organic compounds, particularly in the formation of alkenes from aldehydes and ketones through the Wittig reaction. This reaction is a widely employed method for the preparation of alkenes with high levels of stereoand regioselectivity.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, PROPARGYLTRIPHENYLPHOSPHONIUM BROMIDE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its ability to facilitate the formation of alkenes makes it a crucial component in the development of complex molecular structures found in many drugs.
Used in Research and Development:
PROPARGYLTRIPHENYLPHOSPHONIUM BROMIDE is also used in research and development settings, where it aids chemists in exploring new synthetic pathways and developing novel compounds with potential applications in various fields, including medicine, agriculture, and materials science.
Used in Chemical Synthesis:
In the broader field of chemical synthesis, PROPARGYLTRIPHENYLPHOSPHONIUM BROMIDE is employed as a versatile reagent for the preparation of a wide range of organic compounds. Its utility in the Wittig reaction allows for the efficient synthesis of complex molecules, making it a valuable asset in the development of new chemical products and materials.
Purification Methods
It recrystallises from 2-propanol as white plates. It also crystallises from EtOH with m 156-158o. IR has max 1440, 1110cm1 (P-C str). [Elter & Dediger Justus Liebigs Ann Chem 682 62 1965, Schweizer et al. J Org Chem 42 200 1977].
Check Digit Verification of cas no
The CAS Registry Mumber 2091-46-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,0,9 and 1 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2091-46:
(6*2)+(5*0)+(4*9)+(3*1)+(2*4)+(1*6)=65
65 % 10 = 5
So 2091-46-5 is a valid CAS Registry Number.
InChI:InChI=1/C21H18P/c1-2-18-22(19-12-6-3-7-13-19,20-14-8-4-9-15-20)21-16-10-5-11-17-21/h1,3-17H,18H2/q+1
2091-46-5Relevant articles and documents
An Elegant Synthesis of a New Class of 1-(Substituted)-1H-1,2,3-triazol-4-yl)methyl)diphenylphosphineoxides by Microwave Irradiation
Chinthaparthi, Radha Rani,Gangireddy, Chandra Sekhar Reddy,Kandula, Madhu Kumar Reddy,Balam, Satheesh Krishna,Cirandur, Suresh Reddy
, p. 1876 - 1882 (2015/11/09)
A simple and efficient one-pot microwave-assisted click formation of 1-(substituted)-1H-1,2,3-triazol-4-yl)methyl)diphenylphosphineoxide derivatives via Huisgen regioselective [3+2]-cycloaddition of an in situ generated organic azides and diphenyl(prop-2-yn-1-yl)phosphine oxide in highly polar DMSO-H2O medium. This synthetic protocol is mild, requires shorter reaction time, and afforded products in excellent yields with high regioselectivity.
Synthesis of chlorophyll-a homologs by Wittig and Knoevenagel reactions with methyl pyropheophorbide-d
Tamiaki, Hitoshi,Kouraba, Mitsuru
, p. 10677 - 10688 (2007/10/03)
The formyl group at the 3-position of methyl pyropheophorbide-d reacted with phosphorous ylides and activated methylene compounds to give efficiently the corresponding 3-(2-substituted ethenyl)chlorins compounds as a product of Wittig and Knoevenagel reactions. The trans-isomers of the synthetic chlorins, methyl 32-substituted pyropheophorbide-a had visible bands absorbing longer wavelengths than the cis-isomers and the 32-unsubstituted chlorin, methyl pyropheophorbide-a. 32,32-Disubstitution strongly affected the absorption bands compared with the bands of the 32-monosubstituted chlorins. The absorption, fluorescence and circular dichroism spectra were dependent upon the 3-substituents conjugated with the chlorin chromophore.
