21003-56-5

Basic information

• Product Name: N,N-di(1-phenylethyl)amine
• Synonyms: N,N-di(1-phenylethyl)amine
• CAS NO: 21003-56-5
• Molecular Weight: 225.334
• Mol File: 21003-56-5.mol
• Article Data: 85

Chemical Properties

• CAS DataBase Reference: N,N-di(1-phenylethyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-di(1-phenylethyl)amine(21003-56-5)
• EPA Substance Registry System: N,N-di(1-phenylethyl)amine(21003-56-5)

Safety Data

• Hazardous Substances Data: 21003-56-5(Hazardous Substances Data)

Upstream product

• 613-91-2 acetophenone oxime 
• 540-69-2 ammonium formate 
• 98-86-2 acetophenone 
• 917-64-6 methyl magnesium iodide 
• 92-29-5 hydrobenzamide 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 10341-75-0 (E)-1-phenylethanone oxime 
• 585-71-7 (1-bromoethyl)benzne 
• 100-52-7 benzaldehyde 
• 98-85-1 1-Phenylethanol 
• 618-36-0 rac-methylbenzylamine 
• 40636-57-5 (αS)-α-methyl-N-(1-phenylethylidene)benzenemethanamine 
• 69350-13-6 N-benzylidene-(S)-α-methylbenzylamine 
• 40648-92-8 hydrochloride salt of (1S,1'S)-bis(1-phenylethyl)amine 

Downstream Products

• 134431-04-2 tert-butyl (3R,αR,α'R)-3-(N,N-bis(α-methylbenzyl)amino)butanoate 
• 134431-03-1 benzyl (3R,αR,α'R)-3-(N,N-bis(α-methylbenzyl)amino)butanoate 
• 137219-70-6 2-{[Bis-((S)-1-phenyl-ethyl)-amino]-methyl}-acrylic acid tert-butyl ester 
• 90933-78-1 C₁₆H₁₈NO 
• 197387-11-4 lithium (S,S)-bis(α-methylbenzyl)amide 
• 712352-08-4 (3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-(1-phenyl-ethyl)-amine 
• 364782-99-0 N,N-bis[(1R)-1-phenylethyl]prop-2-enamide 
• 409365-86-2 (S,S)-(-)-N,N-bis(1-phenylethyl)acrylamide 
• 108462-22-2 methyl (S,S)-N,N-bis(1-phenylethyl)carbamate 
• 500103-26-4 O,O'-(1,1'-biphenyl-2,2'-diyl)-N,N'-bis[(S,S)-1-phenyl-ethyl]phosphoramidite 
• 787629-78-1 dimethyl (R,R)-(+)-3-N,N-bis(α-methylbenzyl)-amino-2-oxopropylphosphonate 
• 118699-86-8 1-(α-methylbenzyl)-2-methyl-2-phenyl-1H-pyrrol-3(2H)-one 

Relevant articles and documents

Origin of 1, 3-induction in the addition of alkyl lithium to imines bearing an N-stereogenic center

The origin of diastereoselectivity in the addition of alkyl lithium to chiral Schiff bases has been investigated experimentally and theoretically and the formation of the major diastereomer can be explained from the energy minimized structure of the Schiff base in which the phenyl group has been found to orient in such a manner that it posed lesser steric hindrance to the incoming nucleophile as compared to the alkyl group.

Method for synthesizing chiral phosphite ligand based on R - 2 - phenylethylamine

The invention discloses a method for synthesizing chiral phosphite ligand based on R - 2 -phenylethylamine. To the method, R - 2 -phenylethylamine is reacted with acetophenone to obtain the imine intermediate, and then is mixed with H. 2 Under

Scalable preparation of stable and reusable silica supported palladium nanoparticles as catalysts for N-alkylation of amines with alcohols

The development of nanoparticles-based heterogeneous catalysts continues to be of scientific and industrial interest for the advancement of sustainable chemical processes. Notably, up-scaling the production of catalysts to sustain unique structural features, activities and selectivities is highly important and remains challenging. Herein, we report the expedient synthesis of Pd-nanoparticles as amination catalysts by the reduction of simple palladium salt on commercial silica using molecular hydrogen. The resulting Pd-nanoparticles constitute stable and reusable catalysts for the synthesis of various N-alkyl amines using borrowing hydrogen technology without the use of any base or additive. By applying this Pd-based catalyst, functionalized and structurally diverse N-alkylated amines as well as some selected drug molecules were synthesized in good to excellent yields. Practical and synthetic utility of this Pd-based amination protocol has been demonstrated by upscaling catalyst preparation and amination reactions to several grams-scales as well as recycling of catalyst. Noteworthy, this Pd-catalyst preparation has been up-scaled to kilogram scale and catalysts prepared in both small (1 g) and large-scale (kg) exhibited similar structural features and activity.